J Korean Cancer Assoc.  1998 Feb;30(1):31-39.

Prognostic Value of p53 and Proliferating Cell Nuclear Antigen ( PCNA ) in Stage 3 Gastric Carcinoma

• Oh HT
• Lee DS
• Han DH
• Kim SY
• Ahn BY
• Kim MC
• Joo MJ
• Lee KM
• Kim WY
• Sin SH

Abstract

PURPOSE
We evaluated the prognostic significance of p53 and proliferating cell nuclear antigen(PCNA) in stage III gastric carcinoma to determine the correlation between the p53 and PCNA expression and various clinicopathological parameters.
MATERIALS AND METHODS
The expression of p53 and PCNA were studied immunohistochemically in 64 cases of stage III gastric carcinomas with paraffin-embedded tissue specimens which were obtained surgically at the department of surgery, Presbyterian Medical Center from 1991 to 1992. Both expression were compared with known factors of prognosis. Survival rate and other clinicopathological parameters were analysed.
RESULTS
Expression rates of p53 and high PCNA group were 40.6% and 26.6%, respectively. There was no significant correlation between the p53 and PCNA expression and various clinicopathological variables such as age, sex, stage, histology, tumor depth, number of metastatic node, tumor size, site and method of operation. To analyse survival, we evaluated overall survival according to the extent of p53 and PCNA expression. No significant correlations between the p53 and PCNA expression and overall survival were found.
CONCLUSION
These results suggest that the p53 and PCNA expression seems to be hard to use as a prognostic indicator in stage III gastric carcinoma.

Keyword

Stage III gastric carcinoma; Prognostic significance; p53; PCNA

MeSH Terms

Prognosis
Proliferating Cell Nuclear Antigen*
Protestantism
Survival Rate
Proliferating Cell Nuclear Antigen