Intest Res.  2012 Oct;10(4):365-371. 10.5217/ir.2012.10.4.365.

Clinicopathological Characteristics of Colorectal Cancer according to Gender Difference

Affiliations
  • 1Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. drcha@khu.ac.kr

Abstract

BACKGROUND/AIMS
Colorectal cancer (CRC) has been one of the major causes of death and has become a major public health concern. The incidence of CRC has been increasing regardless of gender in Korea. Until now, however, the studies on gender-based clinicopathological characteristics of CRC focused on pathology have never been reported. Therefore, we aimed to evaluate the difference in clinicopathological characteristics of CRC according to gender in Korea.
METHODS
Medical records of 342 patients with advanced CRC who underwent surgical resection at Kyung Hee University Hospital at Gangdong from June 2006 to December 2011 were retrospectively analyzed. The data of the clinicopathological characteristics of CRC by gender difference were compared.
RESULTS
Of these 341 patients, 203 (60%) patients were male and 138 (40%) patients were female. The male preponderance was noted in all age groups for total CRC and left-sided CRC. However, for right-sided colon cancer, this male preponderance was significantly decreased with increasing age groups (P=0.025) and was finally reversed in elderly groups (age > or =60 years). The microsatellite instability represented by negative staining for hMLH1 and hMSH2 was more frequently detected in women than men (P=0.037).
CONCLUSIONS
The male preponderance in right-sided colon cancer decreased with increasing age groups and finally reversed in age groups more than 60 years. Microsatellite instability with immunohistochemical staining was more frequently detected in women. However, further studies with a large number of patients are warranted on this issue.

Keyword

Colorectal Neoplasms; Gender Identity; Pathology; Microsatellite Instability

MeSH Terms

Aged
Cause of Death
Colonic Neoplasms
Colorectal Neoplasms
Female
Gender Identity
Humans
Incidence
Korea
Male
Medical Records
Microsatellite Instability
Negative Staining
Public Health
Retrospective Studies
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