Diabetes Metab J.  2015 Aug;39(4):328-334. 10.4093/dmj.2015.39.4.328.

Maximal Fat Oxidation Rate during Exercise in Korean Women with Type 2 Diabetes Mellitus

• Suk MH
• Moon YJ
• Park SW
• Park CY
• Shin YA

• KMID: 2174029
• DOI: http://doi.org/10.4093/dmj.2015.39.4.328

Abstract

BACKGROUND
The purpose of this study was to determine the appropriate exercise intensity associated with maximum fat oxidation, improvement of body composition, and metabolic status in Korean women with type 2 diabetes mellitus (T2DM).
METHODS
The study included a T2DM group (12 women) and a control group (12 women). The groups were matched in age and body mass index. The subjects performed a graded exercise test on a cycle ergometer to measure their maximal fat oxidation (Fatmax). We also measured their body composition, metabolic profiles, and mitochondrial DNA (mtDNA).
RESULTS
The exercise intensity for Fatmax was significantly lower in the T2DM group (34.19% maximal oxygen uptake [VO2 max]) than the control group (51.80% VO2 max). Additionally, the rate of fat oxidation during exercise (P<0.05) and mtDNA (P<0.05) were significantly lower in the T2DM group than the control group. The VO2 max level (P<0.001) and the insulin level (P<0.05) were positively correlated with the rate of fat oxidation.
CONCLUSION
The results of this study suggest lower exercise intensity that achieves Fatmax is recommended for improving fat oxidation and enhancing fitness levels in Korean women with T2DM. Our data could be useful when considering an exercise regimen to improve health and fitness.

Keyword

Diabetes mellitus, type 2; Exercise prescription; Maximal fat oxidation; Maximal oxygen uptake

MeSH Terms

Body Composition
Body Mass Index
Diabetes Mellitus, Type 2*
DNA, Mitochondrial
Exercise Test
Female
Humans
Insulin
Metabolome
Oxygen
DNA, Mitochondrial
Insulin
Oxygen

Figure

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  Fig. 1 Comparison of the maximal fat oxidation (Fatmax) intensity (A) and fat oxidation rate at the Fatmax intensity (B) between the type 2 diabetes mellitus (T2DM) and the control groups. aP<0.05.

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  Fig. 2 Comparison of fat oxidation in the type 2 diabetes mellitus (T2DM) and the control groups. VO2 max, maximal oxygen uptake. aP<0.05.

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  Fig. 3 Linear correlation of fat oxidation with (A) maximal oxygen uptake (VO2 max) and (B) insulin.

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