J Korean Diabetes.  2014 Sep;15(3):146-150. 10.4093/jkd.2014.15.3.146.

Glucose Lowering Effect of SGLT2 Inhibitors: A Review of Clinical Studies

• Kim HJ

• KMID: 2173886
• DOI: http://doi.org/10.4093/jkd.2014.15.3.146

Abstract

There are numerous glucose lowering agents in clinical use for type 2 diabetic patients, yet most do not achieve glycemic targets. Recently, inhibitors of the sodium glucose cotransporter 2 (SGLT2) have been developed, which show great potential of being a novel therapeutic option to treat type 2 diabetes. Many researches have turned their attention to the kidney as a target because renal glucose reabsorption is increased in type 2 DM. SGLT2 is a protein transporter that mediates glucose reabsorption from glomerular filtrates. In an insulin-independent manner, inhibition of SGLT2 increases urinary glucose excretion and decreases plasma glucose levels. To date, there are a few SGLT2 inhibiting agents being clinically studied both as a monotherapy and in combination with other antidiabetic agents. This review will focus on the efficacy of SGLT2 inhibitors based on clinical studies.

Keyword

Hypoglycemic agents; Sodium glucose cotransporter 2; Type 2 diabetes mellitus

MeSH Terms

Blood Glucose
Diabetes Mellitus, Type 2
Glucose*
Humans
Hypoglycemic Agents
Kidney
Protein Transport
Sodium
Glucose
Hypoglycemic Agents
Sodium

Figure

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  Fig. 1. Changes in glycated hemoglobin (HbA1C) in trials with sodium glucose cotransporter 2 inhibitors. PBO, placebo. Adapted from Fujita Y et al. J Diabetes Investig. 2014;5:265-75[3].

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