A Comparative Study of Breast Cancer of Korean Women according to Age in Radiological, Pathological, and Clinical Findings

Lee, Young Rahn; Seo, Bo Kyoung; Chung, Kyoo Byung; Cho, Kyu Ran; Lee, June Young; Lee, Young Hen; Noh, Hyung Joon; Lee, Seung Hwa; Woo, Ok Hee; Je, Bo Kyung; Kim, Kyoung Rae; Kim, Jung Hyuk; Bae, Jeoung Won; Kim, In Sun

Abstract

PURPOSE: The incidence of breast cancer is continuously increasing in Korea, and the age of the initially detected breast cancer is younger than western people. The purpose of this study was to compare radiological, pathological, and clinical findings of breast cancers according to age and then contribute to the basis of screening program of breast cancer.
METHODS
Retrospectively, the 325 patients who had pathologically confirmed breast cancer were included in this study. The patients were classified into 6 groups according to age, 20~29, 30~39, 40~49, 50~59, 60~69, and more than 70 years. We evaluated the radiological findings of 325 cases of mammography and 144 cases of breast ultrasonography, classified as four types; mass, microcalcification, others, and non-detected lesion, and then analyzed radiological findings according to age. We evaluated pathological and clinical findings according to age and compared with radiological findings. We used Mantel-Haenszel's chi 2 test and trend test for comparison according to age.
RESULTS
The incidence of breast cancer was 61 cases (19%) in 30~39 years, 122 (38%) in 40~49 years, 92 (28%) in 50~59 years. Most of breast cancer was invasive ductal carcinoma, 258 (79%) and in situ carcinoma was 32 (10%). Most of in situ carcinoma was detected in 20~59 years, 31/32 (97%). Mammography showed mass in 237 (73%), microcalcification in 45 (14%), other finding in 13 (4%), and non-detected lesion in 30 (9%). Twenty-one (47%) of 45 cases with microcalcification were in situ carcinoma and most of in situ carcinoma was presented as microcalcification on mammography, 21/32 (66%). In twenty-eight of 30 cases (93%) with non-detected lesion on mammography, breast cancer was detected on ultrasonography. In terms of clinical findings, there was no symptom in 12/32 (38%) with in situ carcinoma and 57/258 (22%) with invasive ductal carcinoma.
CONCLUSION
The incidence of breast cancer is abruptly increasing from 4th decades and there is no significant difference in radiological and clinical findings according to age. But, most of in situ carcinoma was detected in 20~59 years and presented as microcalcification on mammography. Thus, Screening mammography should be considered from 4th decades.