J Gynecol Oncol.  2010 Mar;21(1):56-58. 10.3802/jgo.2010.21.1.56.

Cellular fibroma of the ovary containing Leydig cell hyperplasia: a case report

• Yoon BS
• Seong SJ
• Park CT
• Park H
• Shim JY
• Kim JY

• KMID: 2173515
• DOI: http://doi.org/10.3802/jgo.2010.21.1.56

Abstract

Ovarian stromal tumors containing Leydig cell components are rare. Only a few cases of ovarian stromal Leydig cell tumors characterized by clusters of Leydig cells have been reported to date. Here, we present the first case report of a 65-year-old woman with a cellular fibroma of the ovary containing Leydig cell hyperplasia. Microscopic examination revealed the proliferation of spindle cells arranged in intersecting bundles with mild nuclear atypia and an average of 2-3 mitotic figures per ten high-power fields. Multifocal nests of polygonal cells with abundant eosinophilic cytoplasm and round nuclei were seen within the spindle cells. Final pathology of the tumor revealed a cellular fibroma including Leydig cell hyperplasia.

Keyword

Ovary; Fibroma; Leydig cells

MeSH Terms

Aged
Cellular Structures
Cytoplasm
Eosinophils
Female
Fibroma
Humans
Hyperplasia
Leydig Cell Tumor
Leydig Cells
Male
Ovary

Figure

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  Fig. 1 Cellular fibroma area showing a cellular proliferation of intersecting bundles of spindle cells with mild nuclear atypia. (A) ×100, (B) ×200.

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  Fig. 2 Multifocal areas of Leydig cell hyperplasia, consisting of nests of polygonal cells with abundant eosinophilic cytoplasm and round nuclei within the cellular fibroma. (A), (B) ×200.

Reference

1. Roth LM. Recent advances in the pathology and classification of ovarian sex cord-stromal tumors. Int J Gynecol Pathol. 2006. 25:199–215.

2. Roth LM. Fox H, Wells M, editors. Sex cord-stromal tumours of the ovary. Haines & Taylor obstetrical and gynaecological pathology. 1995. New York: Churchill Livingstone;823–845.

3. Zhang J, Young RH, Arseneau J, Scully RE. Ovarian stromal tumors containing lutein or Leydig cells (luteinized thecomas and stromal Leydig cell tumors): a clinicopathological analysis of fifty cases. Int J Gynecol Pathol. 1982. 1:270–285.

4. Sternberg WH, Roth LM. Ovarian stromal tumors containing Leydig cells: I. Stromal-Leydig cell tumor and non-neoplastic transformation of ovarian stroma to Leydig cells. Cancer. 1973. 32:940–951.

5. Konishi I, Fujii S, Ishikawa Y, Suzuki A, Okamura H, Mori T. Ovarian fibroma with Leydig cell hyperplasia of the adjacent stroma: a light and electron microscopic study. Int J Gynecol Pathol. 1986. 5:170–178.