Ann Dermatol.  2011 Aug;23(3):379-381. 10.5021/ad.2011.23.3.379.

A Case of Myxoid Dermatofibrosarcoma Protuberans

• Hong YJ
• Choi YW
• Myung KB
• Choi HY

• KMID: 2171934
• DOI: http://doi.org/10.5021/ad.2011.23.3.379

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a slowly growing dermal spindle cell tumor and its myxoid variant, a rare type of DFSP, is characterized by extensive myxoid degeneration. We present the case of a 69-year-old woman with a multinodular reddish plaque on her trunk. Histopathologically, the tumor was located in the dermis and consisted of uniform spindle-shaped cells, showing strongly positive reaction for CD34, and negative for both S-100 and desmin. In addition to the typical storiform pattern, prominent myxoid stromal changes were demonstrated. Herein, we report an interesting case of myxoid DFSP, rarely reported in the dermatology literature.

Keyword

Dermatofibrosarcoma protuberans; Myxoid variant

MeSH Terms

Aged
Dermatofibrosarcoma
Dermatology
Dermis
Desmin
Female
Humans
Dermatofibrosarcoma
Desmin

Figure

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  Fig. 1 Multinodular reddish plaques, with partial gelatinous appearance on the abdomen.

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  Fig. 2 The diffusely infiltrating tumor was located in the entire dermis (H&E, ×40).

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  Fig. 3 (A) The tumor showed the characteristic storiform pattern in some parts of the lesion (H&E, ×100). (B) In addition to the typical storiform pattern, prominent myxoid stromal changes were demonstrated (H&E, ×100). (C) Bland spindle cells with oval nuclei were randomly embedded in the loose myxoid stroma (H&E, ×400).

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  Fig. 4 (A) The tumor cells were strongly positive for CD34 (CD34, ×40).

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