Ann Dermatol.  2011 Dec;23(Suppl 3):S322-S325. 10.5021/ad.2011.23.S3.S322.

Porokeratotic Eccrine Ostial and Dermal Duct Nevus Showing Partial Remission by Topical Photodynamic Therapy

• Kim WJ
• Choi SR
• Lee HJ
• Kim DH
• Yoon MS

• KMID: 2171862
• DOI: http://doi.org/10.5021/ad.2011.23.S3.S322

Abstract

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is an uncommon, benign dermatosis and is characterized by asymptomatic grouped keratotic papules and plaques with a linear pattern on the extremities. Various treatments, including topical steroids, topical calcipotriol, topical 5-fluorouracil, retinoid, cryotherapy, and carbon dioxide laser ablation have been tried for PEODDN, but the results were unsatisfactory. Recently, topical photodynamic therapy (PDT) has been shown to be effective for various cutaneous disorders. We report a case of PEODDN showing partial remission with PDT using topical 5-aminolevulanic acid in a 4-year-old girl.

Keyword

Photodynamic therapy; Porokeratotic eccrine ostial and dermal duct nevus

MeSH Terms

Calcitriol
Cryotherapy
Extremities
Fluorouracil
Lasers, Gas
Nevus
Photochemotherapy
Preschool Child
Skin Diseases
Steroids
Triazenes
Calcitriol
Fluorouracil
Steroids
Triazenes

Figure

• 

  Fig. 1 (A) Verrucous plaques on the right forearm (arrow heads) and multiple keratotic papules in a linear distribution on the right ring and little fingers. (B) Multiple coalescent punctate pits with central keratotic plugs on the right sole.

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  Fig. 2 (A) Multiple keratotic papules on the flexural side of the right ring and little fingers and punctate pits with central keratotic plugs on the right palm before photodynamic therapy (PDT). (B) Uptake of 5-aminolevulanic acid at distal and middle phalanges of the right ring finger shown with fluorescence photography under Wood's light. (C) Partial remission: one year after 2 treatment sessions of PDT.

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  Fig. 3 A skin biopsy specimen showed cornoid lamella-like parakeratotic columns with central dilated acrosyringia and loss of the granular layer (H&E, ×100).

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