Ann Dermatol.  2011 Dec;23(Suppl 3):S288-S289. 10.5021/ad.2011.23.S3.S288.

Acute Generalized Exanthematous Pustulosis Caused by Daptomycin

• Leng TY
• Aan MK
• Chan M
• Tsien LT

• KMID: 2171853
• DOI: http://doi.org/10.5021/ad.2011.23.S3.S288

Abstract

Daptomycin, a lipopeptide antibiotic with similar action as vancomycin, is used to treat complicated skin and soft tissue infections caused by resistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, penicillin-resistant streptococci, and vancomycin-resistant enterococci. Acute generalized exanthematous pustulosis (AGEP), characterized by acute onset of numerous sterile, nonfollicular pinhead sized pustules, is common secondary to drugs, in particular, antibiotics. We present the first case of AGEP following the use of daptomycin.

Keyword

Acute generalized exanthematous pustulosis; Daptomycin

MeSH Terms

Acute Generalized Exanthematous Pustulosis
Anti-Bacterial Agents
Daptomycin
Gram-Positive Bacteria
Methicillin-Resistant Staphylococcus aureus
Skin
Soft Tissue Infections
Vancomycin
Anti-Bacterial Agents
Daptomycin
Vancomycin

Figure

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  Fig. 1 Histology shows subcorneal pustules with perivascular lymphoplasmacytic infiltrates admixed with neutrophils and occasional eosinophils (H&E, ×100).

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