Ann Dermatol.  2013 May;25(2):263-265. 10.5021/ad.2013.25.2.263.

Selective Elevation of Antibodies to Desmoglein 1 during the Transition from Mucocutaneous to Cutaneous Type Pemphigus Vulgaris

• Matsuda-Hirose H
• Ishikawa K
• Goto M
• Hatano Y
• Fujiwara S

• KMID: 2171808
• DOI: http://doi.org/10.5021/ad.2013.25.2.263

Abstract

No abstract available.

MeSH Terms

Antibodies
Desmoglein 1
Desmogleins
Pemphigus
Antibodies
Desmoglein 1
Desmogleins

Figure

• 

  Fig. 1 Alteration of serum levels of antibodies to desmoglein (DSG) 1 and 3 and of clinical severity score. Serum levels of antibodies to desmoglein 1 and 3 fluctuated in parallel with disease severity on the stage of mucocutaneous type of pemphigus vulgaris (PV). On the stage of cutaneous type of PV, levels of antibodies to DSG1 (but not DSG3) fluctuated in parallel with disease severity. Each item in the severity index was scored from a minimum of 0 to a maximum of 3, and included: (i) the ratio of the affected area of skin to the total skin area as a percentage (0, none; 1, <5%; 2, 5~15%; and 3, >15%) (ii) the number of newly developed blisters per day (0, none; 1, occasional blisters; 2, 1~5 blisters; and 3, >5 blisters) and (iii) the presence or absence of oral lesions as a percentage (0, none; 1, <5%; 2, 5~30%; and 3, >30%). Consequently, the severity of a case was rated by the total of the scores.

• 

  Fig. 2 Clinical and histopathological findings. (A) On the stage of cutaneous type of pemphigus vulgaris, highly-crusted and scaly erythema with partial erosions appeared on her scalp. Histologic examination of the erosion on her scalp disclosed suprabasilar acantholysis and papillomatosis without any apparent sign of superficial blister formation. (B) H&E, ×40.

Reference

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