Ann Dermatol.  2013 May;25(2):208-212. 10.5021/ad.2013.25.2.208.

Eccrine Angiomatous Hamartoma: A Review of Ten Cases

• Shin J
• Jang YH
• Kim SC
• Kim YC

• KMID: 2171790
• DOI: http://doi.org/10.5021/ad.2013.25.2.208

Abstract

BACKGROUND
Eccrine angiomatous hamartoma (EAH) is a rare benign nodular lesion characterized by the proliferation of eccrine and vascular structures, generally capillaries, in the middle and deep dermis. It may be congenital or appear later in childhood, but rarely arises in adulthood.
OBJECTIVE
To investigate the clinicopathologic features of EAH in Korean patients.
METHODS
Ten cases of EAH diagnosed at Ajou University Hospital and Gangnam Severance Hospital in Korea from 2007 to 2010 were retrospectively reviewed.
RESULTS
The age range of patients was between 5 and 66 years with an equal number of male and female patients. Apart from two congenital cases, the onset was late, ranging from 6 months to 65 years of age. All lesions were solitary and located on the distal extremities. Nine cases appeared as a yellow-brown nodule or plaque resembling a callus. Neither hyperhidrosis nor hypertrichosis was documented. Apart from the typical histological findings of EAH, prominent mucin deposition, fat component and nerve infiltration were observed.
CONCLUSION
This is one of the largest single case series of EAH in the literature. Clinically, resemblance to callosities and the frequent occurrence in the adulthood were the unique features in our series.

Keyword

Callosity; Capillary; Eccrine gland; Hamartoma; Neoplasm

MeSH Terms

Bony Callus
Callosities
Capillaries
Dermis
Eccrine Glands
Extremities
Female
Hamartoma
Humans
Hyperhidrosis
Hypertrichosis
Korea
Male
Mucins
Retrospective Studies
Mucins

Figure

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  Fig. 1 A yellow-brown plaque on the right sole, resembling a callus (patient 5).

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  Fig. 2 A bluish nodule on the left second finger (patient 6).

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  Fig. 3 Proliferation of mature eccrine glands and capillaries in the middle to deep dermis of the right second finger (patient 2; H&E, A: ×50, B: ×200).

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  Fig. 4 Proliferation of capillaries delineated by factor VIII-related antigen immunohistochemical staining (patient 4; factor VIII-related antigen, ×200).

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