Ann Dermatol.  2014 Apr;26(2):145-149. 10.5021/ad.2014.26.2.145.

Correlations between Anti-Mast Cell Autoantibodies and Chronic Idiopathic Urticaria

• Sun L
• Erxun K
• Li J
• Yang J
• Han C

• KMID: 2171647
• DOI: http://doi.org/10.5021/ad.2014.26.2.145

Abstract

BACKGROUND
The etiology of chronic idiopathic urticaria (CIU) is not completely clear. There are a few antibodies were reported to correlate with CIU.
OBJECTIVE
To investigate the correlation these antibodies and CIU.
METHODS
The autologous serum skin test (ASST) and allergens were performed. Serum levels of immunoglobulin E (IgE), anti-FcepsilonRI and anti-IgE, anti-Helicobacter pylori (HP) antibodies and anti-thyroglobulin antibody (TGAb) were measured in 100 patients with CIU, acute urticaria (AU) and normal controls respectively.
RESULTS
Eighty-six percent food or inhalant allergens were detected in AU patients, but no allergens were detected in CIU patients and normal controls. Serum anti-FcepsilonRI antibody and anti-IgE antibody levels were higher in the CIU than that in the AU patients and normal controls (p<0.05, respectively). IgE level was lower in the CIU patients (T=190.00, p< 0.05), but increased in the AU patients (T=226.00, p<0.05) compared with the normal controls. The ASST positive rates in the CIU and the AU patients were 53.4% and 12.6% respectively, but all normal controls were negative. The anti-FcepsilonRI antibody level was higher in the ASST-positive CIU patients than those negative ones (T=101.73, p<0.05). In anti-HP antibody positive and TGAb positive CIU patients, anti-FcepsilonRI antibody positive rate was higher than AU patients (p<0.01) and normal controls (p<0.01).
CONCLUSION
The anti-FcepsilonRI and anti-IgE antibodies play a key role in CIU, but anti-HP antibody and TGAb have an indirect correlation with CIU.

Keyword

Antibody; Anti-Helicobacter pylori antibody; Anti-immunoglobulin E antibody; Chronic idiopathic urticaria; Anti-thyroglobulin

MeSH Terms

Allergens
Antibodies
Autoantibodies*
Humans
Immunoglobulin E
Immunoglobulins
Skin Tests
Urticaria*
Allergens
Antibodies
Autoantibodies
Immunoglobulin E
Immunoglobulins

Figure

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  Fig. 1 Positive results of Autologous serum skin test: the serum-injected site manifested a wheal and flare with a diameter at least 1.5 mm greater than that of the saline.

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  Fig. 2 Serum levels of IgE, anti-FcεRI antibody, and anti-IgE antibody in CIU group, AU group and Normal controls. IgE: immunoglobulin E, CIU: chronic idiopathic urticaria, AU: acute urticaria.

Reference

1. Belsito DV. Second-generation antihistamines for the treatment of chronic idiopathic urticaria. J Drugs Dermatol. 2010; 9:503–512.

2. Zuberbier T, Asero R, Bindslev-Jensen C, Walter Canonica G, Church MK, Giménez-Arnau A, et al. Dermatology Section of the European Academy of Allergology and Clinical Immunology. Global Allergy and Asthma European Network. European Dermatology Forum. World Allergy Organization. EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy. 2009; 64:1417–1426.

3. Vohra S, Sharma NL, Mahajan VK. Autologous serum skin test: methodology, interpretation and clinical applications. Indian J Dermatol Venereol Leprol. 2009; 75:545–548.

4. Kaplan AP, Greaves M. Pathogenesis of chronic urticaria. Clin Exp Allergy. 2009; 39:777–787.

5. Huilan Z, Runxiang L, Bihua L, Qing G. Role of the subgroups of T, B, natural killer lymphocyte and serum levels of interleukin-15, interleukin-21 and immunoglobulin E in the pathogenesis of urticaria. J Dermatol. 2010; 37:441–447.

6. Grattan CE, Wallington TB, Warin RP, Kennedy CT, Bradfield JW. A serological mediator in chronic idiopathic urticaria--a clinical, immunological and histological evaluation. Br J Dermatol. 1986; 114:583–590.

7. Konstantinou GN, Grattan CE. The autologous serum skin test may be used as a marker for histamine releasing autoantibodies in urticaria and is not relevant to other subject groups. Clin Exp Dermatol. 2009; 34:e473–e474.

8. Sajedi V, Movahedi M, Aghamohammadi A, Gharagozlou M, Shafiei A, Soheili H, et al. Comparison between sensitivity of autologous skin serum test and autologous plasma skin test in patients with Chronic Idiopathic Urticaria for detection of antibody against IgE or IgE receptor (FcεRIα). Iran J Allergy Asthma Immunol. 2011; 10:111–117.

9. Yadav MK, Rishi JP, Nijawan S. Chronic urticaria and Helicobacter pylori. Indian J Med Sci. 2008; 62:157–162.

10. Başkan EB, Türker T, Gülten M, Tunali S. Lack of correlation between Helicobacter pylori infection and autologous serum skin test in chronic idiopathic urticaria. Int J Dermatol. 2005; 44:993–995.

11. Zauli D, Grassi A, Ballardini G, Contestabile S, Zucchini S, Bianchi FB. Thyroid autoimmunity in chronic idiopathic urticaria: implications for therapy. Am J Clin Dermatol. 2002; 3:525–528.

12. Aamir IS, Tauheed S, Majid F, Atif A. Frequency of autoimmune thyroid disease in chronic urticaria. J Coll Physicians Surg Pak. 2010; 20:158–161.