Ann Dermatol.  2015 Aug;27(4):442-445. 10.5021/ad.2015.27.4.442.

Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review

• Altunay I
• Cerman AA
• Sakiz D
• Ates B

• KMID: 2171504
• DOI: http://doi.org/10.5021/ad.2015.27.4.442

Abstract

Marjolin's ulcer is an aggressive cutaneous malignancy common in previously traumatized or chronically inflamed skin. It has high regional metastasis and fatality rates. Our patient presented with subcutaneous nodules and ulcerations on the right limb. He had a history of osteomyelitis of the fifth toe. Histopathological examination of the nodule and ulceration demonstrated squamous cell carcinoma. The nodules and ulcerations were in-transit metastases of Marjolin's ulcer. Here, we present a case of squamous cell carcinoma arising at a site of a chronic osteomyelitis with resultant in-transit metastases.

Keyword

Metastasis; Leg ulcer; Squamous cell carcinoma

MeSH Terms

Carcinoma, Squamous Cell
Extremities
Humans
Leg Ulcer
Neoplasm Metastasis*
Osteomyelitis
Skin
Toes
Ulcer*

Figure

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  Fig. 1 (A) Irregularly shaped deep ulcerations on the dorsum of the right foot. (B) Multiple erythematous subcutaneous nodules on the right lower extremity.

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  Fig. 2 Development of new ulcerations on the dorsum of the (A) foot and (B) thigh due to in-transit metastases.

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  Fig. 3 Dermal infiltration of atypical squamous cells (H&E, ×100).

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