Ann Dermatol.  2015 Oct;27(5):633-634. 10.5021/ad.2015.27.5.633.

A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit?

• Jung JM
• Lee SH
• Won CH
• Chang SE
• Lee MW
• Choi JH
• Moon KC

• KMID: 2171474
• DOI: http://doi.org/10.5021/ad.2015.27.5.633

Abstract

No abstract available.

MeSH Terms

Acanthoma*
Humans*
Scrotum*

Figure

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  Fig. 1 Multiple well-demarcated <5 mm gray to whitish round papules on the scrotum.

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  Fig. 2 Compact hyperkeratosis with acanthosis. Perinuclear vacuolization, of variable size, of the keratinocytes in the stratum spinosum and stratum granulosum. The keratinocytes exhibited non-well-defined limits that gave the epidermis a reticulate appearance. Hypergranulosis with coarse keratohyalin granules was also observed (H&E, ×200).

Reference

1. Kukreja T, Krunic A. Multiple epidermolytic acanthomas must not be confused with genital human papillomavirus infection. Acta Derm Venereol. 2009; 89:169–171.

2. Kim KH, Yoon MS, Na YJ, Park CS, Oh MR, Moon WC. Development and evaluation of a highly sensitive human papillomavirus genotyping DNA chip. Gynecol Oncol. 2006; 100:38–43.

3. Sun XK, Ma LL, Xie YQ, Zhu XJ. Keratin 1 and keratin 10 mutations causing epidermolytic hyperkeratosis in Chinese patients. J Dermatol Sci. 2002; 29:195–200.

4. Leonardi C, Zhu W, Kinsey W, Penneys NS. Epidermolytic acanthoma does not contain human papillomavirus DNA. J Cutan Pathol. 1991; 18:103–105.

5. Jang BS, Jang HS, Park HJ, Kim MB, Oh CK, Kwon KS. Multiple scrotal epidermolytic acanthomas successfully treated with topical imiquimod. J Dermatol. 2007; 34:267–269.