Ann Dermatol.  2015 Oct;27(5):626-629. 10.5021/ad.2015.27.5.626.

Possible Involvement of Keratinocyte Growth Factor in the Persistence of Hyperpigmentation in both Human Facial Solar Lentigines and Melasma

• Hasegawa K
• Fujiwara R
• Sato K
• Shin J
• Kim SJ
• Kim M
• Kang HY

• KMID: 2171471
• DOI: http://doi.org/10.5021/ad.2015.27.5.626

Abstract

No abstract available.

MeSH Terms

Fibroblast Growth Factor 7*
Humans*
Hyperpigmentation*
Keratinocytes*
Lentigo*
Melanosis*
Fibroblast Growth Factor 7

Figure

• 

  Fig. 1 Immunostaining with an antibody against keratinocyte growth factor (KGF). Significant amount of KGF protein was accumulated in the epidermis of lesional skin compared to that in perilesional normal skin of (A) solar lentigines and (B) melasma (A, B: ×400).

• 

  Fig. 2 Quantitative analysis of immunostaining. Immunohistochemical analysis for keratinocyte growth factor (KGF) was quantified in two ways: the stained area per epidermal area (SA/EA) (A) and the stained area per single rate ridge length (SA/1R) (B). Each measurement was taken under constant magnification. For each frame, the tracing was repeated three times, and the mean±standard deviation was used for evaluation. The image was analyzed by using Image Pro Plus ver. 4.5 (Media Cybernetics Inc., Silver Spring, MD, USA). Comparisons of SA/EA and SA/1R between lesional and perilesional normal skin were done by using two-sided paired Student's t-test. A p-value of <0.05 was considered statistically significant. SPSS ver. 11.0 statistical program (SPSS Inc., Chicago, IL, USA) was used for the analysis. White bar: perilesional normal skin, black bar: lesional skin. Statistically significant differences: *p<0.05, ***p<0.001.

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