Ann Dermatol.  2015 Oct;27(5):622-623. 10.5021/ad.2015.27.5.622.

Adult Multiple Myofibromas on an Atrophic Patch on the Thigh

• Kye H
• Kwon IH
• Seo SH
• Ahn HH
• Kye YC
• Choi JE

• KMID: 2171469
• DOI: http://doi.org/10.5021/ad.2015.27.5.622

Abstract

No abstract available.

MeSH Terms

Adult*
Humans
Myofibroma*
Thigh*

Figure

• 

  Fig. 1 Multiple firm subcutaneous nodules under the atrophic and telangiectatic soft patch on the left thigh.

• 

  Fig. 2 Skin biopsy of the nodule showed well-circumscribed, biphasic tumors (A: H&E, ×12.5) composed of intersecting fascicles of spindle cells (B: H&E, ×200) and a vascular compartment with polygonal cells (C: H&E, ×200). The tumor was positive for smooth muscle actin stain (D: ×40) and negative for desmin (E: desmin, ×40), S-100, and CD34 stains. The skin biopsy of the patch showed nonspecific mild epidermal and dermal atrophy with a small tumor of myofibroma in the dermis (F: H&E, ×12.5).

Reference

1. Granter SR, Badizadegan K, Fletcher CD. Myofibromatosis in adults, glomangiopericytoma, and myopericytoma: a spectrum of tumors showing perivascular myoid differentiation. Am J Surg Pathol. 1998; 22:513–525.

2. Martin AA, Blanchard LE 3rd, Hudgins EM. Adult-onset multiple myofibromas. J Am Acad Dermatol. 2011; 64:610–611.

3. Guitart J, Ritter JH, Wick MR. Solitary cutaneous myofibromas in adults: report of six cases and discussion of differential diagnosis. J Cutan Pathol. 1996; 23:437–444.

4. Kim DS, Lee HJ, Kwon YS, Lee JH. Multiple adult myofibromas with congenital smooth muscle hamartoma. Clin Exp Dermatol. 2009; 34:254–256.

5. Nunnery EW, Kahn LB, Reddick RL, Lipper S. Hemangiopericytoma: a light microscopic and ultrastructural study. Cancer. 1981; 47:906–914.