Ann Dermatol.  2016 Apr;28(2):260-261. 10.5021/ad.2016.28.2.260.

Coexistence of Classic and a Mononuclear Variant of Juvenile Xanthogranuloma in an Adult Patient

• Lee HE
• Kim SJ
• Im M
• Lee Y
• Kim CD
• Lee JH
• Seo YJ

• KMID: 2171392
• DOI: http://doi.org/10.5021/ad.2016.28.2.260

Abstract

No abstract available.

MeSH Terms

Adult*
Humans
Xanthogranuloma, Juvenile*

Figure

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  Fig. 1 (A) A 20-year-old female presented with a 4-month history of a red-to-yellow dome-shaped, asymptomatic, ulcerated nodule on the scalp. (B and C) Subsequently, two small yellow lesions developed on the patient's back and thigh, with similar appearances to the scalp lesion.

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  Fig. 2 (A) Proliferation of monomorphous epithelioid cells with mild lymphocytic infiltrates in the excised lesion from the back (H&E, ×40). (B) Higher magnification demonstrates dense epithelioid to spindle-shaped mononuclear cells without foamy cells and giant cells (H&E, ×100). (C) Heavy dermal infiltrates with conspicuous Touton giant cells in the biopsy specimen of the scalp lesion on the second follow-up (H&E, ×40). (D) Higher magnification demonstrates mixed proliferation of histiocytes, lymphocytes, and Touton giant cells (H&E, ×200). (E) The histiocytes in the specimen were positive for CD68 (CD68 stain, ×40).

Reference

1. Batista AC, Mendonça EF, Arantes Elias LS, Andrade BA, Almeida OP, León JE. Nonlipidized juvenile xanthogranuloma: an unusual variant with a potential diagnostic pitfall. Int J Pediatr Otorhinolaryngol. 2012; 76:295–299.

2. Dehner LP. Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol. 2003; 27:579–593.

3. Fabrizi G, Massi G. Mononuclear variant of juvenile xanthogranuloma in the oral cavity of an adult patient. Br J Dermatol. 2001; 144:909–911.

4. Busam KJ, Rosai J, Iversen K, Jungbluth AA. Xanthogranulomas with inconspicuous foam cells and giant cells mimicking malignant melanoma: a clinical, histologic, and immunohistochemical study of three cases. Am J Surg Pathol. 2000; 24:864–869.

5. Kubota Y, Kiryu H, Nakayama J, Koga T. Histopathologic maturation of juvenile xanthogranuloma in a short period. Pediatr Dermatol. 2001; 18:127–130.