Ewha Med J.  2014 Dec;37(Suppl):S37-S40. 10.12771/emj.2014.37.S.S37.

Amphetamine-Like Weight Reduction Drug Induced Acute Cardiomyopathy with Left Ventricular Thrombosis

  • 1Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea. ysk1140@eulji.ac.kr
  • 2Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.


A 37-year-old female patient admitted due to dyspnea on exertion and peripheral edema. For one and a half years, the patient had been taking various drugs and supplements to reduce weight, including amphetamine-like drugs. The patient had no major cardiovascular risk factors except three pack-years of smoking. A chest computed tomography showed a 1.7 cm diameter, capsulated space-occupying lesion in the left ventricle (LV) and 2-dimensional echocardiography showed LV systolic dysfunction (Left ventricular ejection fraction [LVEF], 30%) with a mobile cystic mass (1.1x1.8 cm) that was attached to the LV apex, which was increased in size and number the next day, even with low dose low-molecular-weight heparin. With an increased dose of anticoagulation medication and heart failure management with diuretics and angiotensin receptor II blocker, LV dysfunction was recovered and the LV thrombus disappeared.


Amphetamine; Cardiomyopathies; Thrombosis
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