Ewha Med J.  1991 Dec;14(4):397-401. 10.12771/emj.1991.14.4.397.

Conservative Treatment of Ectopic Pregnancy with Methotrexate

• Kim CI

• KMID: 2170870
• DOI: http://doi.org/10.12771/emj.1991.14.4.397

Abstract

Seventeen subjects with ectopic pregnancies were treated with five doses of intramuscular methotrexate(25mg) injection follow by five doses of Citovorum factor(3mg). Seventeen subjects were 11 tubal. 4 cornual. and 2 cervical pregnancies. The diagnosis was established in tubal and cornual pregnancies by laparoscopy following sonography and radioimmunoassay for serum beta-subunit of human chorionic gonadotropin. Subjects were followed with every 3 days quantitative serum HCG and sonography. Fifteen of the seveteen subjects experienced resolution of the ectopic mass and was subjected underwent one cornual resection and one salpingectomy. The duration of disappearance of beta-HCG to normal after treatment were 2~6 weeks. The most of all subjects were 2~3 weeks(60%). This experience suggests the methotrexate may be an effective alternative for the treatment of early ectopic pregnancy and useful the treatment of cornual. cervical pregnancy.

MeSH Terms

Chorionic Gonadotropin
Diagnosis
Female
Laparoscopy
Methotrexate*
Pregnancy
Pregnancy, Ectopic*
Radioimmunoassay
Salpingectomy
Chorionic Gonadotropin
Methotrexate