Infect Chemother.  2013 Sep;45(3):339-342. 10.3947/ic.2013.45.3.339.

Catheter-Associated Rhodotorula mucilaginosa Fungemia in an Immunocompetent Host

Affiliations
  • 1Department of Infectious Disease, Dongsan Medical Center, Keimyung University School of Medicine, Daegue, Korea. 121rsy@dsmc.or.kr

Abstract

Rhodotorula species live in the environment, but can also colonize human epithelium, as well as respiratory, and gastrointestinal tracts. Reports of infection, especially in the past 2 decades, have noted increasing numbers of Rhodotorula infections, particularly in immunocompromised hosts, leading it to be considered emerging opportunistic pathogen. The major risk factors for infection were prolonged use of central venous catheters in patients with hematological and solid malignancies who are taking corticosteroids or cytotoxic drugs. Herein, we report a case of catheter-associated fungemia due to R. mucilaginosa in an immunocompetent host. The patient was admitted to the intensive care unit with mechanical ventilation for treatment of community-acquired pneumonia. After 10 days, the patient developed new-onset fever confirmed to be a result of catheter-associated blood-stream infection by R. mucilaginosa. It was successfully treated by catheter removal and intravenous amphotericin B.

Keyword

Fungemia; Rhodotorula; Catheter-associated blood-stream infection

MeSH Terms

Adrenal Cortex Hormones
Amphotericin B
Catheters
Central Venous Catheters
Colon
Epithelium
Fever
Fungemia
Gastrointestinal Tract
Humans
Immunocompromised Host
Intensive Care Units
Pneumonia
Respiration, Artificial
Rhodotorula
Risk Factors
Adrenal Cortex Hormones
Amphotericin B

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Reference

1. Fell JW, Boekhout T, Fonseca A, Scorzetti G, Statzell-Tallman A. Biodiversity and systematics of basidiomycetous yeasts as determined by large-subunit rDNA D1/D2 domain sequence analysis. Int J Syst Evol Microbiol. 2000; 50:1351–1371.
Article
2. Pamidimukkala U, Challa S, Lakshmi V, Tandon A, Kulkarni S, Raju SY. Sepsis and meningoencephalitis due to Rhodotorula glutinis in a patient with systemic lupus erythematosus, diagnosed at autopsy. Neurol India. 2007; 55:304–307.
Article
3. Chung JW, Kim BN, Kim YS. Central venous catheter-related Rhodotorula rubra fungemia. J Infect Chemother. 2002; 8:109–110.
4. Lo Re V, Fishman NO, Nachamkin I. Recurrent catheter-related Rhodotorula rubra infection. Clin Microbiol Infect. 2003; 9:897–900.
5. Lunardi LW, Aquino VR, Zimerman RA, Goldani LZ. Epidemiology and outcome of Rhodotorula fungemia in a tertiary care hospital. Clin Infect Dis. 2006; 43:e60–e63.
6. Tuon FF, de Almeida GM, Costa SF. Central venous catheter-associated fungemia due to Rhodotorula spp. --a systematic review. Med Mycol. 2007; 45:441–447.
Article
7. Villar JM, Velasco CG, Delgado JD. Fungemia due to Rhodotorula mucilaginosa in an immunocompetent, critically ill patient. J Infect Chemother. 2012; 18:581–583.
Article
8. Spiliopoulou A, Anastassiou ED, Christofidou M. Rhodotorula fungemia of an intensive care unit patient and review of published cases. Mycopathologia. 2012; 174:301–309.
Article
9. Kurtzman CP, Robnett CJ. Phylogenetic relationships among yeasts of the 'Saccharomyces complex' determined from multigene sequence analyses. FEMS Yeast Res. 2003; 3:417–432.
Article
10. Galán-Sánchez F, García-Martos P, Rodríguez-Ramos C, Marín-Casanova P, Mira-Gutiérrez J. Microbiological characteristics and susceptibility patterns of strains of Rhodotorula isolated from clinical samples. Mycopathologia. 1999; 145:109–112.
11. Louria DB, Greenberg SM, Molander DW. Fungemia caused by certain nonpathogenic strains of the family Cryptococcaceae. Report of two cases due to Rhodotorula and Torulopsis glabrata. N Engl J Med. 1960; 263:1281–1284.
Article
12. Krcmery V, Laho L, Huttova M, Ondrusova A, Kralinsky K, Pevalova L, Dluholucky S, Pisarcíkova M, Hanzen J, Filka J, Sejnova D, Lisková A, Purgelová A, Szovenyová Z, Koren P. Aetiology, antifungal susceptibility, risk factors and outcome in 201 fungaemic children: data from a 12-year prospective national study from Slovakia. J Med Microbiol. 2002; 51:110–116.
Article
13. Choi YH, Park YS, Jo JH, Hong SK, Chang KH, Song YG, Kim JM. Clinical evalution of the incidence and outcome of patient with fungemia. Korean J Infect Dis. 2000; 32:373–379.
14. Hong HK, Kim YM, Kim SD, Bae CW, Lee HJ. A case of rhodotorula mucilaginosa peritonitis undergoing continuous ambulatory peritoneal dialysis in a neonate with acute renal failure. J Korean Soc Neonatol. 2003; 10:94–98.
15. Park JH, Yang CW, Jin DC, Shin WS, Park IS, Chang YS, Bang BK. Rhodontodular glitinis peritonitis in patient undergoing continuous ambulatory peritoneal dialysis. Korean J Nephrol. 1992; 11:85–87.
16. Tuon FF, Costa SF. Rhodotorula infection. A systematic review of 128 cases from literature. Rev Iberoam Micol. 2008; 25:135–140.
17. Shinde RS, Mantur BG, Patil G, Parande MV, Parande AM. Meningitis due to Rhodotorula glutinis in an HIV infected patient. Indian J Med Microbiol. 2008; 26:375–377.
Article
18. Kiehn TE, Gorey E, Brown AE, Edwards FF, Armstrong D. Sepsis due to Rhodotorula related to use of indwelling central venous catheters. Clin Infect Dis. 1992; 14:841–846.
Article
19. Zaas AK, Boyce M, Schell W, Lodge BA, Miller JL, Perfect JR. Risk of fungemia due to Rhodotorula and antifungal susceptibility testing of Rhodotorula isolates. J Clin Microbiol. 2003; 41:5233–5235.
Article
20. Nunes JM, Bizerra FC, Ferreira RC, Colombo AL. Molecular identification, antifungal susceptibility profile, and biofilm formation of clinical and environmental Rhodotorula species isolates. Antimicrob Agents Chemother. 2013; 57:382–389.
Article
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