Endocrinol Metab.  2016 Mar;31(1):80-85. 10.3803/EnM.2016.31.1.80.

Effects of Short-Term Exenatide Treatment on Regional Fat Distribution, Glycated Hemoglobin Levels, and Aortic Pulse Wave Velocity of Obese Type 2 Diabetes Mellitus Patients

• Hong JY
• Park KY
• Kim BJ
• Hwang WM
• Kim DH
• Lim DM

• KMID: 2169696
• DOI: http://doi.org/10.3803/EnM.2016.31.1.80

Abstract

BACKGROUND
Most type 2 diabetes mellitus patients are obese and have obesity related vascular complications. Exenatide treatment is well known for both decreasing glycated hemoglobin levels and reduction in body weight. So, this study aimed to determine the effects of exenatide on body composition, glycated hemoglobin levels, and vascular stiffness in obese type 2 diabetes mellitus patients.
METHODS
For 1 month, 32 obese type 2 diabetes mellitus patients were administered 5 µg of exenatide twice daily. The dosage was then increased to 10 µg. Patients' height, body weight, glycated hemoglobin levels, lipid profile, pulse wave velocity (PWV), body mass index, fat mass, and muscle mass were measured by using Inbody at baseline and after 3 months of treatment.
RESULTS
After 3 months of treatment, glycated hemoglobin levels decreased significantly (P=0.007). Triglyceride, total cholesterol, and low density lipoprotein levels decreased, while aspartate aminotransferase and alanine aminotransferase levels were no change. Body weight, and fat mass decreased significantly (P=0.002 and P=0.001, respectively), while interestingly, muscle mass did not decrease (P=0.289). In addition to, Waist-to-hip ratio and aortic PWV decreased significantly (P=0.006 and P=0.001, respectively).
CONCLUSION
Effects of short term exenatide use in obese type 2 diabetes mellitus with cardiometabolic high risk patients not only reduced body weight without muscle mass loss, body fat mass, and glycated hemoglobin levels but also improved aortic PWV in accordance with waist to hip ratio.

Keyword

Exenatide; Body composition; Pulse wave analysis

MeSH Terms

Adipose Tissue
Alanine Transaminase
Aspartate Aminotransferases
Body Composition
Body Height
Body Mass Index
Body Weight
Cholesterol
Diabetes Mellitus, Type 2*
Hemoglobin A, Glycosylated*
Humans
Lipoproteins
Obesity
Pulse Wave Analysis*
Triglycerides
Vascular Stiffness
Waist-Hip Ratio
Alanine Transaminase
Aspartate Aminotransferases
Cholesterol
Lipoproteins