Clin Pediatr Hematol Oncol.
2008 Oct;15(2):118-126.
Comparison of Dose between Radiotherapy Alone and Concurrent Radio-chemotherapy in Treatment of Intracranial Germinoma
- Affiliations
-
- 1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. cj@yuhs.ac
- 2Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Neurosurgery, Pochon CHA Unuversity College of Medicine, Seongnam, Korea.
Abstract
-
PURPOSE: Intracranial germinoma is the most frequent intracranial germ cell tumor. Radiotherapy has so far been considered as the standard treatment. Radiotherapy could unfavorably affect the quality of life, so there have been many trials to reduce the radiation dose. We report significant reduction of radiation dose on tumor field when it was combined with chemotherapy.
METHODS
From January 1997 to January 2007, 31 patients were enrolled in this study. 12 patients received radiotherapy alone, 19 patients received radio-chemotherapy. We compared craniospinal irradiation (CSI) dose, total irradiation dose on tumor bed and incidence of CSI between two groups.
RESULTS
There were 21 male and 10 female patients, with a mean age of 19.3 years. Solitary tumors were found in 26 cases (83.9%), multiple tumors in 5 cases (16.1%). All patients were survived. The average CSI dose in radiotherapy alone group was 18.88+/-6.18 Gy and that of radio-chemotherapy group was 13.25+/-9.54 Gy. CSI dose in radiotherapy alone group was higher than that of radio-chemotherapy group (P=0.002). The average total radiation dose in radiotherapy alone group was 38.98+/-2.71 Gy and that of radio-chemotherapy group was 33.87+/-5.55 Gy. The total irradiation dose in radiotherapy alone group was also higher than that of radio-chemotherapy group (P=0.001). The incidence of CSI was higher in radiotherapy alone group (P<0.05).
CONCLUSION
We discovered that there was a significant reduction of radiation dose in radio- chemotherapy group. It suggested that we could reduce the radiation dose in treatment of intracranial germinoma when we combine chemotherapy with radiation therapy, which could reduce the side effects of radiation.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Understanding the Treatment Strategies of Intracranial Germ Cell Tumors: Focusing on Radiotherapy
- Intracranial beta-hCG Secreting Germinoma: Clinical Significance and Radiotherapy Results
- Excluding prepontine cistern from whole ventricle radiotherapy target volume in localized germinoma
- Delayed diagnosis of intramedullary spinal cord germinoma
- A Case of Pineal Germinoma with Drop Metastasis to Cauda Equina
