J Bacteriol Virol.  2009 Dec;39(4):345-351. 10.4167/jbv.2009.39.4.345.

Seroepidemiological Studies of Aino Virus Infection in Korean Cattle

• Cho JJ
• Shin YK
• Yoon S
• Yoon SS
• Lee OS
• Song JY
• Han HR

• KMID: 2168546
• DOI: http://doi.org/10.4167/jbv.2009.39.4.345

Abstract

Aino virus infection is characterized by abortion, stillbirth, and congenital abnormalities such as arthropgryposis-hydranencephaly syndrome in calves. In Korea, Aino virus infection was first reported in 1997 by researchers who were investigating the cause of newborn calf deformities. Given the incidence of Aino-related deformities, the need for a study of the Aino virus infection status in Korea was recognized. In this study, we investigated the nationwide seroepidemiological status of Aino virus infection. A total of 9,921 serum samples collected between 1993 and 2001, and 23,760 serum samples between 2002 and 2007 were tested using a virus neutralization assay. The seroprevalence of Aino virus was 73.1, 63.8, 44.9, 56.0, 38.5, 28.4 18.3, 19.6, and 23.2%, respectively, between 1993 and 2001, and 43.8, 42.9, 50.7, 55.3, 31.4, and 25.4%, respectively, between 2002 and 2007. Aino virus infection does not pose a major threat to the bovine industry in Korea till now. The future prospects for Aino virus infection in cattle, however, may change with the global warming phenomena. The results of this study may serve as a basis for future epidemiological studies on Aino virus infection.

Keyword

Aino virus infection; Seroprevalence; Virus neutralization assay

MeSH Terms

Animals
Cattle
Congenital Abnormalities
Epidemiologic Studies
Global Warming
Humans
Incidence
Infant, Newborn
Korea
Seroepidemiologic Studies
Stillbirth
Viruses

Reference

1). Coverdale OR., Cybinski DH., St George TD. Congenital abnormalities in calves associated with Akabane virus and Aino virus. Aust Vet J. 1978. 54:151–2.

2). Ishibashi K., Shirakawa H., Uchinuno Y., Ogawa T. Seroprevalence survey of Aino virus infection in dairy cattle of Fukuoka, Japan in 1990. J Vet Med Sci. 1995. 57:1–4.

3). Miura Y., Inaba Y., Tsuda T., Tokuhisa S., Sato K., Akashi Hatumoto M. A survey of antibodies to arthropod-borne viruses in Indonesian cattle. Nippon Juigaku Zasshi. 1982. 44:857–63.

4). Tsuda T., Yoshida K., Ohashi S., Yanase T., Sueyoshi M., Kamimura S, et al. Arthrogryposis, hydranencephaly and cerebellar hypoplasia syndrome in neonatal calves resulting from intrauterine infection with Aino virus. Vet Res. 2004. 35:531–8.

5). Weir R. Aino virus. Australia and New Zealand Standard Diagnostic Procedures. 2003.

6). Kurogi H., Inaba Y., Takahashi E., Sato K., Satoda K. Congenital abnormalities in newborn calves after inoculation of pregnant cows with Akabane virus. Infect Immun. 1977. 17:338–43.

7). Uchinuno Y., Noda Y., Ishibashi K., Nagasue S., Shirakawa H., Nagano M., Ohe R. Isolation of Aino virus from an aborted bovine fetus. J Vet Med Sci. 1998. 60:1139–40.

8). Miura Y., Kubo M., Goto Y., Kono Y. Hydranencephaly-cerebellar hypoplasia in a newborn calf after infection of its dam with Chuzan virus. Nippon Juigaku Zasshi. 1990. Aug;. 52(4):689–94.

9). Schmaljohn C., Nichol ST. Bunyaviridae. Fields Virology. 2007. (5th).

10). Takahashi K., Oya A., Okazda T., Matsuo R., Kuma M. Aino virus, a new a new member of simbu group of arbovirus from mosquitoes in Japan. Jpn J Med Sci Biol. 1968. 21:95–101.

11). Doherty RL., Carley JG., Standfast HA., Dyce AL., Snowdon WA. Virus strains isolated from arthropods during an epizootic of bovine ephemeral fever in Queensland. Aust Vet J. 1972. 48:81–6.

12). Yeon Hee Kim SIL., Kwon Chang Hee., Yang Dong Kun. Development of inactivated vaccine for Akabane, Aino and Chuzan Disease. NVRQS Annual Research Report. 2005. 962–75.

13). Yamakawa M., Yanase T., Kato T., Tsuda T. Chronological and geographical variations in the small RNA segment of the teratogenic Akabane virus. Virus Res. 2006. 121:84–92.

14). Tsutsui T., Hamaya Y. Monitoring system and epidemiology on arbovirus infections of cattle in Japan. International Workshop on Arboviral Diseases of Livestock in East Asia. 2009.

15). Akashi H., Onuma S., Nagano H., Ohta M., Fukutomi T. Detection and differentiation of Aino and Akabane Simbu serogroup bunyaviruses by nested polymerase chain reaction. Arch Virol. 1999. 144:2101–9.

16). Fukuyoshi S., Takehara Y., Takahashi K., Mori R. The incidence of antibody to Aino virus in animals and humans in Fukuoka. Jpn J Med Sci Biol. 1981. 34:41–3.

17). Jusa ER., Inaba Y., Ishibashi K., Noda M. Effect of heparin on hemagglutination by Akabane and Aino viruses belonging to the Simbu group of bunyaviruses. Vet Microbiol. 1995. 45:251–8.

18). Kitano Y., Ohzono H., Shimizu T. Proliferation and teratogenicity of Aino virus in chick embryos. Microbiol Immunol. 1996. 40:85–8.

19). Kitano Y., Ohzono H., Yasuda N., Shimizu T. Hydranencephaly, cerebellar hypoplasia, and myopathy in chick embryos infected with aino virus. Vet Pathol. 1996. 33:672–81.

20). Moriwaki M., Miura Y., Hayashi S., Ishitani R. Histopathological findings of calves infected experimentally with Aino virus. Natl Inst Anim Health Q (Tokyo). 1977. 17:95–106.

21). Noda Y., Uchinuno Y., Shirakawa H., Nagasue S., Nagano N., Ohe R, et al. Aino virus antigen in brain lesions of a naturally aborted bovine fetus. Vet Pathol. 1998. 35:409–11.

22). Yamakawa M., Yanase T., Kato T., Tsuda T. Molecular epidemiological analyses of the teratogenic Aino virus based on the sequences of a small RNA segment. Vet Microbiol. 2008. 129:40–7.

23). Yanase T., Yoshida K., Ohashi S., Kato T., Tsuda T. Sequence analysis of the medium RNA segment of three Simbu serogroup viruses, Akabane, Aino, and Peaton viruses. Virus Res. 2003. 93:63–9.

24). Reed M. A simple method of estimating fifty per cent endpoints. Am J Hyg. 1938. 27:493–7.

25). Cho HC., Chong CS. Notes on biting midges of the genus culicoides from South Korea: with special reference to unrecorded species and distribution. Kisaengchunghak Chapchi. 1974. 2:45–75.

26). Miura Y., Inaba Y., Hayashi S. A survey of neutralizing antibody against aino virus in bovine serum in Kagoshima, Japan. Natl Inst Anim Health Q (Tokyo). 1980. 20:34–5.