Cancer Res Treat.  2013 Jun;45(2):150-154.

Multiple Cardiac Metastases from a Nonfunctioning Pancreatic Neuroendocrine Tumor

  • 1Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 2Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea.


Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms, which most commonly metastasize to the liver. However, intrathoracic metastases from pNETs are encountered infrequently. This report describes a case of nonfunctioning pNET with multiple cardiac metastases. A 56-year-old male presented with a palpable abdominal mass that showed progressive enlargement. Findings on computed tomography (CT) of the abdomen revealed two relatively well-marginated inhomogeneous low-attenuation masses, one in the head of the pancreas and the other in the tail. Multiple enhancing masses in the left pericardium with myocardial involvement were observed on chest CT and transthoracic echocardiography. Needle biopsies were performed on the mass in the tail of the pancreas and the left ventricular apical pericardium; histologic examination by hematoxylin and eosin morphology and immunohistochemical staining showed pNET in both. This is the first report of pNET with multiple cardiac metastases to previously undescribed metastatic sites.


Heart neoplasms; Neoplasm metastasis; Neuroendocrine tumors; Pancreas
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