Clin Exp Reprod Med.
2012 Mar;39(1):28-32. 10.5653/cerm.2012.39.1.28.
Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET
- Affiliations
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- 1Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. blasto@snubh.org
- 2Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2167517
- DOI: http://doi.org/10.5653/cerm.2012.39.1.28
Abstract
OBJECTIVE
This study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF.
METHODS
Between May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days post-ET and stored. HCG, progesterone, and inhibin A levels were measured by commercial enzyme-linked immunosorbent assay kits. The predictive accuracy of hCG, progesterone, and inhibin A levels for establishment of intrauterine pregnancy and ongoing pregnancy was calculated by receiver-operating characteristic curve analysis.
RESULTS
For the prediction of intrauterine and ongoing pregnancy, serum hCG was better than progesterone and inhibin A. The predictive performance of progesterone and inhibin A was similar. The serum progesterone and inhibin A levels were significantly correlated each other (r=0.915, p=0.010).
CONCLUSION
A single measurement of the serum hCG level is sufficient to predict pregnancy outcome in IVF-ET patients.
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