Clin Exp Reprod Med.  2015 Dec;42(4):149-155. 10.5653/cerm.2015.42.4.149.

A high response to controlled ovarian stimulation induces premature luteinization with a negative impact on pregnancy outcomes in a gonadotropin-releasing hormone antagonist cycle

• Koo HS
• Cha SH
• Kim HO
• Song IO
• Min EG
• Yang KM
• Park CW

• KMID: 2167478
• DOI: http://doi.org/10.5653/cerm.2015.42.4.149

Abstract

OBJECTIVE
The goal of this study was to investigate the relationship between serum progesterone (P4) levels on the day of human chorionic gonadotropin (hCG) administration and the pregnancy rate among women undergoing controlled ovarian stimulation for in vitro fertilization (IVF) or intracytoplasmic sperm injection-embryo transfer (ICSI-ET) using a flexible antagonist protocol.
METHODS
This prospective study included 200 IVF and ICSI-ET cycles in which a flexible antagonist protocol was used. The patients were divided into five distinct groups according to their serum P4 levels at the time of hCG administration (0.80, 0.85, 0.90, 0.95, and 1.00 ng/mL). The clinical pregnancy rate (CPR) was calculated for each P4 interval. Statistically significant differences were observed at a serum P4 level of 0.9 ng/mL. These data suggest that a serum P4 concentration of 0.9 ng/mL may represent the optimal threshold level for defining premature luteinization (PL) based on the presence of a significant negative impact on the CPR.
RESULTS
The CPR for each round of ET was significantly lower in the PL group defined using this threshold (25.8% vs. 41.8%; p=0.019), and the number of oocytes retrieved was significantly higher than in the non-PL group (17.3+/-7.2 vs. 11.0+/-7.2; p=0.001). Elevated serum P4 levels on the day of hCG administration were associated with a reduced CPR, despite the retrieval of many oocytes.
CONCLUSION
Measuring serum P4 values at the time of hCG administration is necessary in order to determine the optimal strategy for embryo transfer.

Keyword

In vitro fertilization-embryo transfer; Pregnancy outcome; Premature luteinization

MeSH Terms

Cardiopulmonary Resuscitation
Chorionic Gonadotropin
Embryo Transfer
Female
Fertilization in Vitro
Gonadotropin-Releasing Hormone*
Humans
Lutein*
Luteinization*
Oocytes
Ovulation Induction*
Pregnancy
Pregnancy Outcome*
Pregnancy Rate
Pregnancy*
Progesterone
Prospective Studies
Spermatozoa
Chorionic Gonadotropin
Gonadotropin-Releasing Hormone
Lutein
Progesterone