Clin Exp Otorhinolaryngol.  2016 Mar;9(1):62-69. 10.21053/ceo.2016.9.1.62.

Prognostic Impact of Ultrasonography Features and 18F-Fluorodeoxyglucose Uptake in Patients With Papillary Thyroid Microcarcinoma

Affiliations
  • 1Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. docjin@yuhs.ac
  • 2Division of Nuclear Medicine, Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.
  • 3Department of Research Affairs, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
To evaluate the prognostic impact of ultrasonography (US) features and 18F-fluorodeoxyglucose (18F-FDG) uptake in patients with papillary thyroid microcarcinoma (PTMC).
METHODS
This study included 74 patients with a single PTMC diagnosed pathologically. Patients underwent total thyroidectomy, or near-total thyroidectomy and staging thyroid US and positron emission tomography (PET) were performed prior to surgery. US features of thyroid nodules were reviewed retrospectively and the maximum standard uptake value (SUV) of nodules was semiquantitatively analyzed on 18F-FDG PET/computed tomography (CT). Patients were followed-up for recurrence, which was defined as PTC on cytology results, elevated serum thyroglobulin (Tg) or anti-Tg antibody levels, or uptake on whole-body scintigraphy. We used univariate and multivariate analyses to evaluate whether poor prognostic outcomes were associated with US features or SUV values derived from PET/CT of nodules. In addition, subjects were divided into 2 groups for subgroup analyses: one with nodules equal to or larger than 5 mm and one with nodules smaller than 5 mm.
RESULTS
Among the 74 patients, there was no recurrence. Thus we evaluated the correlation between SUV value and US features with poor prognostic factors of PTMC which included extrathyroid extension, central and lateral lymph node (LN) metastasis. However no clinicopathologic factors were associated with extrathyroid extension, central LN metastasis, or lateral LN metastasis.
CONCLUSION
In patients with PTMC, US features and SUV values on FDG-PET were not related to extrathyroid extension or LN metastasis. However, future studies with a larger sample size and longer follow-up should be performed to verify the results of this study.

Keyword

Thyroid; Papillary Thyroid Microcarcinoma; Ultrasonography; Positron Emission Tomography

MeSH Terms

Fluorodeoxyglucose F18
Follow-Up Studies
Humans
Lymph Nodes
Multivariate Analysis
Neoplasm Metastasis
Positron-Emission Tomography
Positron-Emission Tomography and Computed Tomography
Radionuclide Imaging
Recurrence
Retrospective Studies
Sample Size
Thyroglobulin
Thyroid Gland*
Thyroid Nodule
Thyroidectomy
Ultrasonography*
Fluorodeoxyglucose F18
Thyroglobulin

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