Cancer Res Treat.  2010 Mar;42(1):57-60.

Dedifferentiated Liposarcoma of the Retroperitoneum

• Kim ES
• Jang SH
• Park HC
• Jung EH
• Moon GB

Abstract

A dedifferentiated liposarcoma of the retroperitoneum is an extremely rare tumor. A 51-year old man was admitted to our department because a retroperitoneal mass was seen on abdominal computed tomography at another hospital. Computed tomography of the abdomen and magnetic resonance imaging showed a large pelvic mass located in the right hemipelvis, and it was pushing the right ureter and invading the right kidney, duodenum, colon and inferior vena cava. The patient underwent right radical nephrectomy, pylorus preserving pancreatoduodenectomy, right hemicolectomy and artificial blood vessel replacement for the inferior vena cava. The histopathological diagnosis was dedifferentiated liposarcoma and the patient was free from recurrence on the computed tomography that was done 6 months after the operation.

Keyword

Dedifferentiation; Liposarcoma; Retroperitoneum

MeSH Terms

Abdomen
Blood Substitutes
Colon
Duodenum
Glycosaminoglycans
Humans
Kidney
Liposarcoma
Magnetic Resonance Imaging
Nephrectomy
Pancreaticoduodenectomy
Pylorus
Recurrence
Ureter
Vena Cava, Inferior
Blood Substitutes
Glycosaminoglycans

Figure

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  Fig. 1 CT of the abdomen shows a huge fat containing mass in the retroperitoneum. The right kidney, duodenum, inferior vena cava and pancreas are adhered to the mass.

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  Fig. 2 MRI of the abdomen shows a huge solid soft tissue mass.

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  Fig. 3 On sectioning, the tumor mass shows a poorly circumscribed solid cut surface with multifocal necrosis, calcification and discrete intratumoral nodules of varying sizes. The right kidney is partially encased and the mass has grossly infiltrated the surrounding duodenum (thick arrow), the inferior vena cava wall (thin arrow), the pancreas and the colon.

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  Fig. 4 The tumor consisted of a few components. (A) Well-differentiated liposarcoma area (H&E, ×400), (B) a fibrosarcomatous area (H&E, ×200) and (C) myxoid and neural whirling-like spindle cell nodules with multifocal metaplastic ossification (H&E, ×200).

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  Fig. 5 The follow-up CT taken six months after the operation shows no evidence of recurrence.

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