Ann Dermatol.  2016 Jun;28(3):344-351. 10.5021/ad.2016.28.3.344.

CSP0510 Lotion as a Novel Moisturizer Containing Citric Acid and Trisodium Phosphate Relieves Objective and Subjective Symptoms of Atopic Dermatitis

Affiliations
  • 1Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. schul@jnu.ac.kr
  • 2Department of Microbiology, School of Medicine, Chosun University, Gwangju, Korea.

Abstract

BACKGROUND
Moisturizers with anti-inflammatory or anti-itch activity should be developed for the safe and effective management of atopic dermatitis (AD).
OBJECTIVE
This study evaluated the efficacy of a newly developed moisturizer, CSP0510 lotion (Twolines Inc., Korea), containing citric acid (CA) and trisodium phosphate (TSP) as active ingredients, in mild to moderate AD.
METHODS AND RESULTS
CSP0510 lotion applied twice daily for 4 weeks to eczematous lesions improved objective and subjective (itch) symptoms of AD. The physician's global assessment (PGA) score for objective symptoms decreased from 2.5±0.6 before application to 1.3±0.5 after application in the CSP0510-treated group (n=42, p<0.001). Also, the PGA score decreased from 2.3±0.6 to 1.9±0.5 by vehicle-treated (without CA and TSP) control group (p=0.001), but there was no statistical difference between CSP0510-treated and vehicle-treated groups (p=0.089). The visual analogue scale score for itch decreased from 4.8±1.3 to 2.0±0.9 in the CSP0510-treated group (p<0.001), and from 4.6±1.1 to 3.5±0.9 in the control group (p=0.075), showing a statistical significance between two groups (p=0.002). Our results in humans were further supported by in vitro and animal experiments. In HaCaT cells treated with compound 48/80 (7.5 µg/ml), CA:TSP (1:1, vol:vol) synergistically suppressed the compound 48/80-induced upregulation of thymic stromal lymphopoietin, nerve grow factor, and calcitonin gene-related peptide. Application of CSP0510 to the dorsal skin of hairless mice for 3 weeks suppressed the oxazolone-induced allergic skin inflammation.
CONCLUSION
In conclusion, CSP0510 lotion has anti-itch and anti-inflammatory activity in the skin, which improves both objective and subjective symptoms of AD.

Keyword

Anti-inflammatory agents; Atopic dermatitis; Citric acid; CSP0510 lotion; Trisodium phosphate

MeSH Terms

Animal Experimentation
Animals
Anti-Inflammatory Agents
Calcitonin Gene-Related Peptide
Citric Acid*
Dermatitis, Atopic*
Humans
In Vitro Techniques
Inflammation
Mice
Mice, Hairless
Skin
Up-Regulation
Anti-Inflammatory Agents
Calcitonin Gene-Related Peptide
Citric Acid
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