J Korean Med Sci.  2015 Aug;30(8):1207-1208. 10.3346/jkms.2015.30.8.1207.

An Appropriate Lower Respiratory Tract Specimen Is Essential for Diagnosis of Middle East Respiratory Syndrome (MERS)

• Lee JH
• Lee CS
• Lee HB

• KMID: 2164519
• DOI: http://doi.org/10.3346/jkms.2015.30.8.1207

Abstract

No abstract available.

MeSH Terms

Bronchi/microbiology/pathology
Coronavirus Infections/*microbiology/*pathology
Delayed Diagnosis/*prevention & control
Diagnosis, Differential
Diagnostic Errors/*prevention & control
False Positive Reactions
Humans
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Specimen Handling/methods
Sputum/*cytology/*microbiology

Reference

1. Lee J. Better understanding on MERS Corona virus outbreak in Korea. J Korean Med Sci. 2015; 30:835–836.

2. Korea Centers for Disease Control and Prevention. Middle East respiratory syndome Information. accessed on July 2 2015. Available at http://www.mers.go.kr/mers/html/jsp/main.jsp.

3. Zumla A, Hui DS, Perlman S. Middle East respiratory syndrome. Lancet. 2015; DOI: 10.1016/s0140-6736(15)60454-8.

4. Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, Al-Rabiah FA, Al-Hajjar S, Al-Barrak A, Flemban H, Al-Nassir WN, Balkhy HH, Al-Hakeem RF, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013; 13:752–761.

5. Raj VS, Mou H, Smits SL, Dekkers DH, Müller MA, Dijkman R, Muth D, Demmers JA, Zaki A, Fouchier RA, et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature. 2013; 495:251–254.

6. Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, et al. Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs. Am J Respir Crit Care Med. 2013; 188:882–886.

7. van den Brand JM, Smits SL, Haagmans BL. Pathogenesis of Middle East respiratory syndrome coronavirus. J Pathol. 2015; 235:175–184.

8. Yao Y, Bao L, Deng W, Xu L, Li F, Lv Q, Yu P, Chen T, Xu Y, Zhu H, et al. An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus. J Infect Dis. 2014; 209:236–242.

9. de Wit E, Rasmussen AL, Falzarano D, Bushmaker T, Feldmann F, Brining DL, Fischer ER, Martellaro C, Okumura A, Chang J, et al. Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci U S A. 2013; 110:16598–16603.

10. Guery B, Poissy J, el Mansouf L, Séjourné C, Ettahar N, Lemaire X, Vuotto F, Goffard A, Behillil S, Enouf V, et al. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission. Lancet. 2013; 381:2265–2272.

11. Memish ZA, Al-Tawfiq JA, Makhdoom HQ, Assiri A, Alhakeem RF, Albarrak A, Alsubaie S, Al-Rabeeah AA, Hajomar WH, Hussain R, et al. Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome. J Infect Dis. 2014; 210:1590–1594.

12. Poissy J, Goffard A, Parmentier-Decrucq E, Favory R, Kauv M, Kipnis E, Mathieu D, Guery B. MERS-CoV Biology Group. Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases. J Clin Virol. 2014; 61:275–278.

13. Bialek SR, Allen D, Alvarado-Ramy F, Arthur R, Balajee A, Bell D, Best S, Blackmore C, Breakwell L, Cannons A, et al. Centers for Disease Control and Prevention (CDC). First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities - May 2014. MMWR Morb Mortal Wkly Rep. 2014; 63:431–436.