J Korean Med Sci.  2015 Apr;30(4):470-474. 10.3346/jkms.2015.30.4.470.

Coronary Heart Disease in Moyamoya Disease: Are They Concomitant or Coincidence?

• Nam TM
• Jo KI
• Yeon JY
• Hong SC
• Kim JS

• KMID: 2164456
• DOI: http://doi.org/10.3346/jkms.2015.30.4.470

Abstract

The purpose of this study was to determine the prevalence and characteristics of symptomatic coronary heart disease (CHD) in patients with moyamoya disease (MMD). This retrospective study evaluated 456 patients who received examination for MMD between 1995 and 2012. We reviewed the patients' medical history and coronary imaging, including conventional coronary angiography and coronary computed tomography angiogram (CTA). Among 456 patients with MMD, 21 (4.6%) patients were found to have symptomatic CHD. Ten patients were treated with coronary artery bypass graft or percutaneous coronary intervention for unstable angina or myocardial infarction. Eleven were treated with medication for stable angina (n = 6) and variant angina with mild degree of stenosis (n = 5).The median age of these patients was 44 yr (range, 27-59). The median Framingham score at diagnosing MMD was < 1% (range, < 1%-16%). The old age was associated with CHD in uni- and multivariate analyses (P = 0.021, OR, 1.053; 95% CI, 1.008-1.110). Considering low age of onset and low stroke risk factor, CHD might be a systemic manifestation that is clinically relevant to MMD.

Keyword

Moyamoya Disease; Coronary Disease; Prevalence; Characteristics

MeSH Terms

Adult
Age Factors
Aged
Coronary Angiography
Coronary Artery Disease/*etiology
Female
Humans
Logistic Models
Male
Middle Aged
Moyamoya Disease/*complications
Retrospective Studies

Figure

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  Fig. 1 Angiographic findings of coronary heart disease in moyamoya disease. (A) and (B) show coronary stenosis (arrows) without calcification. (C) shows calcified plaque (arrow) on a non-contrast coronary computed tomography, and (D) shows aneurysmal dilatation and focal stenosis (arrow). Nitroglycerin (NG) was administered to the patient.

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