Korean J Gastroenterol.  2014 Nov;64(5):268-277. 10.4166/kjg.2014.64.5.268.

Efficacy of Bisacodyl Given as Part of a Polyethylene Glycol-based Bowel Preparation Prior to Colonoscopy in Hospitalized Patients: A Prospective Ramdomized Trial

• Bang KB
• Jeong EH
• Jeong WS
• Chae HB
• Kim NH
• Lee TH
• Kim JY
• Jung YS
• Park JH
• Sohn CI
• Choi KY
• Park DI

• KMID: 2164429
• DOI: http://doi.org/10.4166/kjg.2014.64.5.268

Abstract

BACKGROUND/AIMS
Inpatient status can cause inadequate bowel preparation. The majority of previous studies regarding bowel preparation have focused on comparing the effects of different purgative regimens in outpatients. However, data on bowel preparation for inpatients are lacking. The aim of this study was to investigate whether bisacodyl plus polyethylene glycol (PEG) can improve bowel preparation in hospitalized patients.
METHODS
A prospective, randomized and observer-blind study was performed. A total of 196 hospitalized patients undergoing colonoscopy were randomized to receive 4 L PEG (PEG only group) or 4 L PEG+bisacodyl 10 mg (bisacodyl added group). The adequacy of bowel preparation was scored using the Ottawa bowel preparation scale.
RESULTS
One hundred and eighty-three subjects completed the study; 96 in the bisacodyl added group and 87 in the PEG only group. There were no significant differences between the bisacodyl added group and the PEG only group with respect to the score of bowel cleansing (3.59+/-2.81 vs. 3.82+/-3.03, p=0.607), quality of bowel cleansing (adequate preparation 89.6% vs. 85.1%, p=0.380), and overall adverse events (66.7% vs. 52.9%, p=0.057). However, a larger proportion of patients in the PEG only group were able to ingest the entire solution as prescribed than in the bisacodyl added group (98.9% vs. 75.0%, p<0.001).
CONCLUSIONS
In hospitalized patients, the quality of bowel preparation did not differ depending on whether bisacodyl is added or not. In addition, patient compliance based on consumption of cleansing agent was better in the PEG only group.

Keyword

Bowel preparation; Bisacodyl; Polyethylene glycols; Inpatients

MeSH Terms

Adult
Aged
Bisacodyl/adverse effects/*therapeutic use
Cathartics/adverse effects/*therapeutic use
Colon/pathology
*Colonoscopy
Female
Humans
Male
Middle Aged
Nausea/etiology
Polyethylene Glycols/adverse effects/*therapeutic use
Prospective Studies
Bisacodyl
Cathartics
Polyethylene Glycols

Figure

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  Fig. 1. Flow sheet of study. PEG, polyethylene glycol.

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  Fig. 2. Comparison of polyethylene glycol (PEG) ingestion between the two groups. The amount of ingested PEG was significantly greater in the 4 L PEG only group than in the 4 L PEG+bisacodyl group (p <0.001).

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  Fig. 3. Patients’ stress to the bowel preparation. 4 L PEG+ bisacodyl 10 mg group suffered more severe stress than 4 L PEG only group (p=0.003).

Reference

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