Korean J Perinatol.  2016 Mar;27(1):36-44. 10.14734/kjp.2016.27.1.36.

Risk Factors of Cystic Periventricular Leukomalacia in Preterm Infants with Gestational Ages of Less Than 32 Weeks according to Gestational Age Group

• Shim GH
• Chey MJ

• KMID: 2164267
• DOI: http://doi.org/10.14734/kjp.2016.27.1.36

Abstract

PURPOSE
The aim of the study was to determine the incidence of cystic periventricular leukomalacia (PVL) and identify the risk factors for cystic PVL in preterm infants with gestational age (GA) less than 32 weeks according to gestational age group.
METHODS
The medical records and brain imaging were reviewed for preterm infants with less than 32 weeks GA who lived more than 4 weeks and admitted to the neonatal intensive care unit at Inje University Sanggye Paik Hospital from January 2009 to June 2015. We determined the incidence and the risk factors for the development of cystic PVL in preterm infants according to GA group.
RESULTS
Incidence of cystic PVL was 15.1% (26/172). Multivariate analysis showed that intraventricular hemorrhage (IVH) [P=0.006, odds ratio (OR) 5.478, 95% confidence interval (CI) 1.641-18.285), oxygen uses over 28 days (P=0.025, OR 3.086, 95% CI 1.152-8.264), and NEC (P=0.042, OR 3.731, 95% CI 1.047-13.333) were independent risk factors for the developmental of cystic PVL. Subgroup analysis showed that pregnancy-induce hypertension and IVH were independent risk factors in preterm infants with GA of less than 28 weeks. Also, oxygen uses over 28 days and culture proven sepsis were independent risk factors in preterm infants with GA of 28(+0)-31(+6) weeks.
CONCLUSION
These results suggest that pregnancy-induce hypertension and IVH may increase the risk for the subsequent development of cystic PVL in preterm infants with GA of less than 28 weeks, and oxygen uses over 28 days and culture proven sepsis may increase in preterm infants with GA of 28(+0)-31(+6) weeks.

Keyword

Cystic periventricular leukomalacia; Preterm infants; Intraventricular hemorrhage; Necrotizing enterocolitis

MeSH Terms

Enterocolitis, Necrotizing
Gestational Age*
Hemorrhage
Humans
Hypertension
Incidence
Infant, Newborn
Infant, Premature*
Intensive Care, Neonatal
Leukomalacia, Periventricular*
Medical Records
Multivariate Analysis
Neuroimaging
Odds Ratio
Oxygen
Risk Factors*
Sepsis
Oxygen

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