J Korean Med Sci.  2012 Nov;27(11):1354-1358. 10.3346/jkms.2012.27.11.1354.

Onodera's Prognostic Nutritional Index as a Risk Factor for Mortality in Peritoneal Dialysis Patients

• Kang SH
• Cho KH
• Park JW
• Yoon KW
• Do JY

• KMID: 2157946
• DOI: http://doi.org/10.3346/jkms.2012.27.11.1354

Abstract

The aim of this study was to evaluate the clinical relevance and usefulness of the Onodera's prognostic nutritional index (OPNI) as a prognostic and nutritional indicator in peritoneal dialysis (PD) patients. Patients were divided into 3 groups based on the initial OPNI score: group A (n = 186, < 40), group B (n = 150, 40-45), and group C (n = 186, > 45). Group A was associated with a higher grade according to the Davies risk index than the other groups. Serum creatinine and albumin levels, total lymphocyte count, and fat mass increased with an increase in OPNI. According to the edema index, the correlation coefficient for OPNI was -0.284 and for serum albumin was -0.322. Similarly, according to the C-reactive protein (CRP), the correlation coefficient for OPNI was -0.117 and for serum albumin was -0.169. Multivariate analysis adjusted for age, Davies risk index, CRP, and edema index revealed that the hazard ratios for low OPNI, serum albumin, and CRP were 1.672 (P = 0.003), 1.308 (P = 0.130), and 1.349 (P = 0.083), respectively. Our results demonstrate that the OPNI is a simple method that can be used for predicting the nutritional status and clinical outcome in PD patients.

Keyword

Onodera's Prognostic Nutritional Index; Peritoneal Dialysis; Nutrition; Mortality; Albumin; Edema index

MeSH Terms

Adult
Age Factors
Aged
Body Fat Distribution
C-Reactive Protein/analysis
Creatinine/blood
Female
Humans
Kaplan-Meier Estimate
Lymphocyte Count
Male
Middle Aged
*Nutrition Assessment
Peritoneal Dialysis/*mortality
Proportional Hazards Models
Risk Factors
Serum Albumin/analysis
Serum Albumin
Creatinine
C-Reactive Protein

Figure

• 

  Fig. 1 Kaplan-Meier survival curve according to Onodera's prognostic nutritional index group (5-yr survival rate, 48.8% for < 40, 72.2% for 40-45, 77.1% for > 45; P < 0.001).

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