J Korean Med Sci.  2005 Dec;20(6):994-999. 10.3346/jkms.2005.20.6.994.

Coronary-artery Calcium Scores Using Electron Beam CT in Patients with Chronic Renal Failure

• Kim CD
• Cho JH
• Choi HJ
• Jang MH
• Kwon HM
• Kim JC
• Park SH
• Lee JM
• Cho DK
• Kim YL

• KMID: 2157751
• DOI: http://doi.org/10.3346/jkms.2005.20.6.994

Abstract

We evaluated the risk of coronary-artery disease in patients with chronic renal failure (CRF) by measuring the coronary-artery calcium scores with electron beam CT (EBCT). A total of 81 CRF patients were divided into three groups; pre-dialysis (group I, n=35), hemodialysis (group II, n=31) and peritoneal dialysis (group III, n=15). The several serum biochemical markers and calcium score levels by EBCT were determined. The Ca x P products were significantly higher in groups II (p<0.05) and III (p<0.01) than in group I. The serum calcium levels were significantly higher in group III than in both group I (p<0.01) and II (p<0.05). The serum calcium level in 15 patients with a calcium score > 400 was significantly higher than the 66 patients with a score < or =400 (p<0.01). The calcium score was significantly higher in the 15 patients with cardiovascular complications than in the 66 patients without cardiovascular complications (628.9+/-904.8 vs. 150.4+/-350.9, p<0.01). EBCT seemed to be a good diagnostic tool for evaluating the risk of coronary-artery disease ''noninvasively'' in CRF patients who are at increased risk of cardiovascular morbidity and mortality.

Keyword

Kidney Failure, Chronic; Coronary-artery Calcium Score; Coronary Vessels; Tomography, X-Ray Computed; Electron Beam CT (EBCT); Calcification, Physiologic; Arteriosclerosis; Parathyroid Hormone

MeSH Terms

Adolescent
Adult
Aged
Calcinosis/etiology/metabolism/*radiography
Calcium/blood/*metabolism
Coronary Arteriosclerosis/etiology/metabolism/radiography
Coronary Vessels/*metabolism
Female
Humans
Kidney Failure, Chronic/complications/metabolism/*radiography/therapy
Male
Middle Aged
Peritoneal Dialysis
Renal Dialysis
Research Support, Non-U.S. Gov't
Risk Factors
Tomography, X-Ray Computed

Figure

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  Fig. 1 Serum calcium and phosphorus levels according to coronary-artery calcium score (CACS).

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  Fig. 2 Serum calcium-phosphorus product according to coronary-artery calcium score (CACS).

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  Fig. 3 Serum parathyroid hormone according to coronary-artery calcium score (CACS).

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  Fig. 4 Distribution of the coronary-artery calcium score (CACS) level according to presence or absence of cardiovascular complications (CVC).

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