Ann Dermatol.  2015 Dec;27(6):744-747. 10.5021/ad.2015.27.6.744.

Venous Leg Ulcer in a Sarcoidosis Patient: A Case Report

• Ohn J
• Byun SY
• Kim IS
• Park KC

• KMID: 2157452
• DOI: http://doi.org/10.5021/ad.2015.27.6.744

Abstract

Venous leg ulcers, the most common form of leg ulcers, are relevant to the pathogenicity of pericapillary fibrin cuff. Sarcoidosis, a multiorgan granulomatous disease, causes fibrin deposition in tissues. We report a case of a 50-year-old man with venous leg ulcers coexisting with sarcoidosis. On the basis of the histologic findings, we propose the hypothesis that sarcoidosis patients are prone to the development of venous leg ulcers.

Keyword

Capillaries; D-dimer; Fibrin; Sarcoidosis; Venous leg ulcer

MeSH Terms

Capillaries
Fibrin
Humans
Leg Ulcer*
Leg*
Middle Aged
Sarcoidosis*
Virulence
Fibrin

Figure

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  Fig. 1 (A) Painful ulcers with yellowish material and hyperpigmentation on both lower legs, especially on both ankles. (B) Multiple erythematous macules with ulcer and crust on the torso.

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  Fig. 2 (A) Thick eosinophilic material layer overlying the spongiotic epidermis. (B) Dermal fibrosis and perivascular lymphocytic infiltration. (C) Extravasation of red blood cells with lymphocytes in the dermis. A~C: H&E.

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  Fig. 3 (A) Focal parakeratosis with acanthosis. (B) Perivascular lymphohistiocytic infiltration in the dermis. A, B: H&E.

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  Fig. 4 Pathophysiologic hypothesis: accelerated venous leg ulcer formation in a sarcoidosis patient.

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