Ann Dermatol.  2011 Oct;23(Suppl 2):S254-S257. 10.5021/ad.2011.23.S2.S254.

Hidradenoma Papilliferum Occurring on the Nasal Skin

• Lee HJ
• Lee D
• Jung SY
• Hong SK
• Seo JK
• Sung HS

• KMID: 2156803
• DOI: http://doi.org/10.5021/ad.2011.23.S2.S254

Abstract

Hidradenoma papilliferum is a rare benign neoplasm that usually occurs in the female anogenital area. We present a 43-year-old female with a non-anogenital (ectopic) hidradenoma papilliferum on her nose. The patient had had a skin-colored subcutaneous nodule on her nose for 7 years. The histopathological findings showed variously shaped cystic spaces in the tumor. And the lumina were surrounded by a single or double layer of cell which showed decapitation secretion. In the English dermatological literature, only one case of ectopic hidradenoma papilliferum arising in nasal skin has been reported. Hence we suggest hidradenoma papilliferum occurring on the nasal skin is a peculiar and interesting event.

Keyword

Ectopic; Hidradenoma papilliferum; Nose

MeSH Terms

Acrospiroma
Adult
Decapitation
Female
Humans
Nose
Skin

Figure

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  Fig. 1 Solitary, 10-mm sized, pink-brown, elevated, firm nodule with smooth surface on the nasal skin was seen.

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  Fig. 2 Variously shaped cystic and tubular structures were lined with a double or single layer of inner columnar and outer cuboidal cells. The cells of the lumina showed decapitation secretion similar to that of apocrine gland (A: H&E, ×40, B: H&E, ×200).

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  Fig. 3 Positive reactivity with gross cystic disease fluid protein is seen (immunoperoxidase, ×40).

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  Fig. 4 Positive reactivity with epithelial membrane antigen is seen (immunoperoxidase, ×40).

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  Fig. 5 Cytoplasm of these cells is negative for carcinoembryonic antigen (immunoperoxidase, ×40).

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