Ann Dermatol.  2011 Sep;23(Suppl 1):S79-S83. 10.5021/ad.2011.23.S1.S79.

Eccrine Porocarcinoma Presenting with Unusual Clinical Manifestations: A Case Report and Review of the Literature

• Choi CM
• Cho HR
• Lew BL
• Sim WY

• KMID: 2156758
• DOI: http://doi.org/10.5021/ad.2011.23.S1.S79

Abstract

Eccrine porocarcinoma is a rare neoplasm that originates from the intraepidermal ductal portion of the eccrine sweat gland, and it usually occurs on the pre-existing lesion of benign eccine poroma. Its occurrence is more common in females and elderly persons. We present a case of a 44-year-old man who suffered from eccrine porocarcinoma, which developed on the right scrotum and pelvic area with metastases to the lung, adrenal gland, esophagus, ureter, and distant lymph nodes. Here we report on a unique case of eccrine porocarcinoma that developed primarily on the scrotum, which is an uncommon site, and showed rapid metastasis to the internal organs.

Keyword

Atypical clinical manifestations; Eccrine porocarcinoma; Neoplasm metastasis; Scrotum

MeSH Terms

Adrenal Glands
Adult
Aged
Eccrine Porocarcinoma
Esophagus
Female
Humans
Lung
Lymph Nodes
Neoplasm Metastasis
Poroma
Scrotum
Sweat Glands
Ureter

Figure

• 

  Fig. 1 (A, B) A firm and ulcerated right scrotum covered with hyperemic granulation tissue. (C) Multiple 1.2×1.0 cm-sized, well-demarcated nodules on the right pelvic area.

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  Fig. 2 (A) Well-defined tumor nests composed of polygonal or cuboidal cells invade the dermis and subcutaneous fat layer. Note the connection between the epidermis and tumor (H&E stain, ×40). (B) This high-grade tumor show area of necrosis (H&E stain, ×200). (C) The malignant cells have hyperchromatic, vesicular, and atypical nuclei with frequent mitoses. Ductal structures are present(H&E stain, ×400).

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  Fig. 3 Immunoperoxidase stain shows positivity for (A) EMA and (B) CK-7, and negativity for (C) CEA.

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  Fig. 4 PET CT scans (A, B). Extensive metastasis involving the cervical, left supraclavicular, mediastinal, abdominopelvic and inguinal lymph nodes. Metastatic lesions on the (C) right lung (D) and right adrenal gland on the CT scans (arrow).

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