Ann Dermatol.  2011 Sep;23(Suppl 1):S64-S67. 10.5021/ad.2011.23.S1.S64.

Vulval Metastasis from Squamous Cell Carcinoma of the Cervix Clinically Presenting as Lymphangioma Circumscriptum

Affiliations
  • 1Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea. drkmp@hanmail.net
  • 2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Abstract

Patients with cervical cancer may develop local recurrence or distant metastasis, and the rate of these events is increased in proportion to the clinical stage. Cutaneous metastasis of cervical cancer is very rare and only a few cases have been reported in Korean literature. It is common at the abdominal wall, vulva, and anterior chest wall and mainly presents as an asymptomatic dermal or subcutaneous nodule, ulcer or plaque. We herein report on an interesting case of vulval metastasis from squamous cell carcinoma of the cervix with an unusual clinical manifestation resembling lymphagioma circumscriptum.

Keyword

Uterine cervical neoplasms; Neoplasm metastasis; Vulva

MeSH Terms

Abdominal Wall
Carcinoma, Squamous Cell
Cervix Uteri
Female
Humans
Lymphangioma
Neoplasm Metastasis
Recurrence
Thoracic Wall
Ulcer
Uterine Cervical Neoplasms
Vulva

Figure

  • Fig. 1 Multiple skin-colored papules and vesicles with focal coalescence on the vulva.

  • Fig. 2 Infiltrating tumor nests were observed in the dermis, which were composed of moderately differentiated squamous cells (A: H&E stain, ×100). Tumor cells were positive at Ki-67 (B: ×200) with a high labeling index (≥50%) and pan-cytokeratin staining (C: ×200) with a cytoplasmic pattern; some tumor cells were observed in the lymphatic channel (D: D2-40 stain, ×400).


Reference

1. Chung HH, Jang MJ, Jung KW, Won YJ, Shin HR, Kim JW, et al. Cervical cancer incidence and survival in Korea: 1993-2002. Int J Gynecol Cancer. 2006. 16:1833–1838.
Article
2. Imachi M, Tsukamoto N, Kinoshita S, Nakano H. Skin metastasis from carcinoma of the uterine cervix. Gynecol Oncol. 1993. 48:349–354.
3. Park JY, Lee HS, Cho KH. Cutaneous metastasis to the scalp from squamous cell carcinoma of the cervix. Clin Exp Dermatol. 2003. 28:28–30.
Article
4. Maheshwari GK, Baboo HA, Ashwathkumar R, Dave KS, Wadhwa MK. Scalp metastasis from squamous cell carcinoma of the cervix. Int J Gynecol Cancer. 2001. 11:244–246.
Article
5. Pertzborn S, Buekers TE, Sood AK. Hematogenous skin metastases from cervical cancer at primary presentation. Gynecol Oncol. 2000. 76:416–417.
Article
6. Martínez-Palones JM, Gil-Moreno A, Pérez-Benavente MA, Martinez-Palones JM, Garcia-Giménez A, Xercavins J. Umbilical metastasis after laparoscopic retroperitoneal paraaortic lymphadenectomy for cervical cancer: a true port-site metastasis? Gynecol Oncol. 2005. 97:292–295.
Article
7. Deka D, Gupta N, Bahadur A, Dadhwal V, Mittal S. Umbilical surgical scar and vulval metastasis secondary to advanced cervical squamous cell carcinoma: a report of two cases. Arch Gynecol Obstet. 2010. 281:761–764.
Article
8. Behtash N, Ghaemmaghami F, Yarandi F, Ardalan FA, Khanafshar N. Cutaneous metastasis from carcinoma of the cervix at the drain site. Gynecol Oncol. 2002. 85:209–211.
Article
9. Park JH, Kim JO, Kim BC, Lee KS. Two cases of cutaneous metastasis from carcinoma of cervix. Korean J Dermatol. 2000. 38:1508–1511.
10. Kim JS, Cho CH, Park SH, Kim YS, Kim KT, Kim HC. A case of skin metastasis from uterine cervical cancer. Korean J Gynecol Oncol Colposc. 2000. 11:411–415.
Article
11. Lee JS, Noh HT, Rhee YE, Lee KH, Ko YB. One case of vulva metastasis from cervical squamous cell carcinoma. Korean J Obstet Gynecol. 2009. 52:368–371.
12. Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol. 1995. 33:161–182.
Article
13. Gönül M, Cakmak SK, Soylu S, Kiliç A, Gündüz H, Gül U, et al. Lymphangioma circumscriptum of the vulva: a case report. Acta Derm Venereol. 2009. 89:180–181.
14. Stewart CJ, Chan T, Platten M. Acquired lymphangiectasia ('lymphangioma circumscriptum') of the vulva: a report of eight cases. Pathology. 2009. 41:448–453.
Article
15. Malfetano JH. Skin metastases from cervical cancer: a fatal event. Gynecol Oncol. 1986. 24:177–182.
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