Ann Dermatol.  2011 Sep;23(Suppl 1):S33-S35. 10.5021/ad.2011.23.S1.S33.

Fixed Drug Eruption due to Iopromide (Ultravist(R))

Affiliations
  • 1Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. yymmpark6301@hotmail.com
  • 2Regional Phamacovigilence Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

A 69-year-old male presented with several painful erythematous patches on both palms and trunk several days after receiving iopromide (Ultravist(R), Shering, Berlin, Germany). A fixed drug eruption (FDE) due to iopromide was suspected clinically. However, at that time, the patch test with iopromide at the lesion site gave negative results. Three years later, the patient was mistakenly administered iopromide again and patches with vesicles recurred on the same sites as well as on the genitalia. This episode was repeated once again after 1 year. In all episodes, the skin lesion resolved after application of topical steroids. Although a patch test with iopromide was negative in our case, we made a diagnosis of FDE due to iopromide because the skin lesions occurred again at the previously involved area after re-exposure to iopromide. To date, only three cases of FDE caused by non-ionic monomers have been documented in the English literature. Herein, we report on an interesting case of FDE caused by iopromide.

Keyword

Contrast media; Fixed drug eruption; Iopromide; Non-ionic monomer

MeSH Terms

Aged
Berlin
Contrast Media
Drug Eruptions
Genitalia
Humans
Iohexol
Male
Patch Tests
Skin
Steroids
Contrast Media
Iohexol
Steroids

Figure

  • Fig. 1 Clinical features of the second episode: painful erythematous patches on both palms and trunk several days after receiving iopromide (Ultravist®, Shering, Berlin, Germany).

  • Fig. 2 Clinical features of the third episode: skin lesions on the same area and also on the left arm after re-exposure to iopromide.

  • Fig. 3 Chemical structure of iopromide (Ultravist®, Shering, Berlin, Germany).


Cited by  1 articles

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Jisu Shim, Soojie Chung, Gun-Woo Kim, Kyoung-Hee Sohn, Ju-Young Kim, Hye-Ryun Kang
Allergy Asthma Respir Dis. 2015;3(5):375-379.    doi: 10.4168/aard.2015.3.5.375.


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