Ann Dermatol.  2011 Sep;23(Suppl 1):S4-S7. 10.5021/ad.2011.23.S1.S4.

Solitary Type of Congenital Self-healing Reticulohistiocytosis

• Dorjsuren
• Kim HJ
• Jung JY
• Bae BG
• Lee JH

• KMID: 2156739
• DOI: http://doi.org/10.5021/ad.2011.23.S1.S4

Abstract

Congenital self-healing reticulohistiocytosis is a rare, congenital, benign, self-healing variant of Langerhans cell histiocytosis. It usually appears as multiple papules or nodules; however, occurrence of the solitary type is very rare. We report on a case of solitary congenital self-healing reticulohistiocytosis in a 29-day-old girl who presented with a papule on her sole. Two months later, the lesion regressed with a slight scar. Based upon clinical and histologic findings, we made a diagnosis of solitary congenital self-healing reticulohistiocytosis. In this report, we summarized reported cases of solitary congenital self-healing retioculohistiocytosis in Korea with a review of the literature.

Keyword

Congenital self-healing reticulohistiocytosis; Solitary

MeSH Terms

Cicatrix
Histiocytosis, Langerhans-Cell
Korea

Figure

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  Fig. 1 (A) A dome-shaped papule with central crust measuring 7 mm on the left sole. (B) Regressed lesion with scar after 2 months.

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  Fig. 2 (A) Hematoxylin and eosin staining revealed atrophic epidermis, effacement of rete ridges, and a dense infiltrate of histiocytes admixed with numerous eosinophils and some lymphocytes (H&E, ×100). (B) Histiocytes showed a large, round, or reniform nuclei, with prominent nucleoli and eosinophilic ground glass cytoplasm (H&E, ×400).

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  Fig. 3 Strong S-100 protein (A) and CD1a (B) expressions are noted in the majority of tumor cells (Immunoperoxidase stain, ×200).

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