Ann Dermatol.  2011 May;23(2):236-238. 10.5021/ad.2011.23.2.236.

A Case of Perifollicular Fibroma

• Nam JH
• Min JH
• Lee GY
• Kim WS

• KMID: 2156672
• DOI: http://doi.org/10.5021/ad.2011.23.2.236

Abstract

Perifollicular fibroma (PFF) is a very rare proliferative lesion of the perifollicular sheath. A flesh-colored, dome-shaped papulonodule is usually located on the face or the neck. These papulonodules may be single or multiple. Histologically, the lesion consists of a concentric arrangement of cellular fibrous tissue around a normal hair follicle. We describe here an unusual case of PFF in a 41-year-old female who had an asymptomatic small skin colored papule on the scalp, and this is an uncommon location for PFF.

Keyword

Perifollicular fibroma; Scalp

MeSH Terms

Adult
Female
Fibroma
Hair Follicle
Humans
Neck
Scalp
Skin

Figure

• 

  Fig. 1 A solitary, 0.5×0.5 cm-sized, flesh-colored, dome-shaped papule on the scalp.

• 

  Fig. 2 The hair follicle is surrounded by a dense concentric fibrous sheath (A: H&E, ×40, B: H&E, ×100).

• 

  Fig. 3 Masson's trichrome staining shows concentric layers of collagen around the follicle (Masson's trichrome, ×40).

• 

  Fig. 4 Increased CD34-positive cells within the fibrosis (CD34, ×200).

Reference

1. Cho S, Hahm JH. Perifollicular fibroma. J Eur Acad Dermatol Venereol. 1999. 13:46–49.

2. Zackheim HS, Pinkus H. Perifollicular fibromas. Arch Dermatol. 1960. 82:913–917.

3. Sasai S, Takahashi K, Tagami H. Coexistence of multiple perifollicular fibromas and colonic polyp and cancer. Dermatology. 1996. 192:262–263.

4. Junkins-Hopkins JM, Cooper PH. Multiple perifollicular fibromas: report of a case and analysis of the literature. J Cutan Pathol. 1994. 21:467–471.

5. Balfour E, Smoller BR. Exogenous trauma simulating perifollicular fibromas. Am J Dermatopathol. 2005. 27:42–44.

6. Burnier MM, Rejsek P. Fibromas sores-cutaneus peripilaries multiples die. Corr Bull Soc Franc Dermatol Syphiligr. 1925. 32:46–49.

7. Ogawa E, Okuyama R, Tagami H, Aiba S. Perifollicular fibroma: a case successfully diagnosed with deeply cut sections. J Dermatol. 2008. 35:126–128.

8. Freeman RG, Chernosky ME. Perifollicular fibroma. Arch Dermatol. 1969. 100:66–69.

9. Headington JT. Tumors of the hair follicle. A review. Am J Pathol. 1976. 85:479–514.

10. Choi EH, Bang DS. Multiple perifollicular fibromas. Ann Dermatol. 1990. 2:68–69.

11. Collins GL, Somach S, Morgan MB. Histomorphologic and immunophenotypic analysis of fibrofolliculomas and trichodiscomas in Birt-Hogg-Dube syndrome and sporadic disease. J Cutan Pathol. 2002. 29:529–533.

12. Ahmed TSS, Priore JD, Seykora JT. Elder DE, Elenitsas R, Johnson BL, Murphy GF, Xu X, editors. Tumor of the epidermal appendages. Lever's histopathology of the skin. 2009. 10th ed. Philadelphia: Lippincott Williams & Wilkins;851–909.

13. Lee DW, Park JS, Choi SW, Cho BK. A case of perifollicular fibroma. Korean J Dermatol. 1993. 31:999–1002.