Ann Dermatol.  2011 May;23(2):229-231. 10.5021/ad.2011.23.2.229.

Imiquimod as an Adjuvant Treatment Measure for Desmoplastic Trichoepithelioma

• Seo SH
• Kim GW
• Sung HW

• KMID: 2156670
• DOI: http://doi.org/10.5021/ad.2011.23.2.229

Abstract

Desmoplastic trichoepithelioma is a rare benign adnexal tumor. Although it is a benign lesion, patients often want to treat it due to cosmetic concerns when it occurs in an easily visible site. For our two cases, topical 5% imiquimod was an attractive treatment option as it is applied by the patients themselves and it has minimal side effects, including leaving no scar. However, the lesions recurred after clinical remission. To the best of our knowledge, this is the only report on utilizing imiquimod to treat a benign adnexal tumor, and especially desmoplastic trichoepithelioma.

Keyword

Adjuvant therapy; Desmoplastic trichoepithelioma; Imiquimod; Recurrence

MeSH Terms

Aminoquinolines
Cicatrix
Cosmetics
Humans
Recurrence
Aminoquinolines
Cosmetics

Figure

• 

  Fig. 1 Clinical findings. Before (A) and 6 months after the application of imiquimod cream three times per week for 6 weeks (B) in case 1. Before (C), after 9 weeks of imiquimod trial three times per week (D) and 10 weeks after discontinuing the treatment (E) in case 2.

• 

  Fig. 2 Histopathologic findings. (A) There are nests and strands of basaloid cells surrounded by a dense fibrous stroma and many horn cysts (H&E, ×200). (B) Recurred desmoplastic trichoepithelioma (H&E, ×100).

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