Ann Dermatol.  2009 Nov;21(4):389-392. 10.5021/ad.2009.21.4.389.

Ecthyma Gangrenosum: A Rare Cutaneous Manifestation Caused by Stenotrophomonas maltophilia in a Leukemic Patient

• Son YM
• Na SY
• Lee HY
• Baek JO
• Lee JR
• Roh JY

• KMID: 2156502
• DOI: http://doi.org/10.5021/ad.2009.21.4.389

Abstract

Ecthyma gangrenosum (EG) is a well-recognized cutaneous infection that most commonly affects immunocompromised patients. It typically occurs on the extremities, or in gluteal and perineal regions. Although Pseudomonas aeruginosa is the most well-known pathogen causing EG, other organisms have been reported to cause EG. Herein we report a rare case of ecthyma gangrenosum presenting as aggressive necrotic skin lesions in perioral and infraorbital areas in a 47-year-old patient with acute myelocytic leukemia after allogeneic bone marrow transplantation. It was caused by Stenotrophomonas maltophilia, which is an aerobic, gram-negative pathogen that has been associated only rarely with cutaneous disease. Blood culture and tissue culture were positive for S. maltophilia. Histological examination revealed numerous tiny bacilli in the dermis and perivascular area. Early recognition of skin lesions caused by S. maltophilia is important to decrease associated mortality in immunosuppressed patients.

Keyword

Ecthyma gangrenosum; Stenotrophomonas maltophilia

MeSH Terms

Bone Marrow Transplantation
Dermis
Ecthyma
Extremities
Humans
Immunocompromised Host
Leukemia, Myeloid, Acute
Middle Aged
Pseudomonas aeruginosa
Skin
Stenotrophomonas
Stenotrophomonas maltophilia

Figure

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  Fig. 1 Severe edematous erythematous necrotic plaques with perioral bullae formation.

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  Fig. 2 (A) Skin biopsy specimen showing subepidermal blister with hemorrhage and dermal edema with vascular congestion (H&E, ×100). (B) Perivascular cuffing with basophilic deposits accompanied by a mixed inflammatory infiltrate of lymphocytes and histiocytes in dermis. Intravascular thrombosis was present with endothelial swelling (H&E, ×200).

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  Fig. 3 Numerous gram-negative bacilli surround papillary dermal vessels and infiltrate the tissue (Gram stain, ×1,000).

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