Korean J Anesthesiol.  2000 Jun;38(6):S6-S12. 10.4097/kjae.2000.38.6.S6.

The Effect of Induced Hypotension on Intraoperative Blood Loss during Spinal Surgery

• Park CK

• KMID: 2155269
• DOI: http://doi.org/10.4097/kjae.2000.38.6.S6

Abstract

BACKGROUND: This study was performed to evaluate whether the degree of hypotension influences blood loss during spinal surgery. METHOD: Fifty patients undergoing only one level spinal fusion were assigned to one of three groups. In group 1 (n = 14), the systolic blood pressure (SBP) was maintained at 100 120 mmHg with enflurane. In groups 2 (n = 18) and 3 (n = 18), the SBP were maintained at 80 100 and 60 80 mmHg, respectively. Hydralazine and esmolol were used in the hypotensive groups.
RESULTS
Blood losses during operation in groups 2 (554 +/- 287 ml) and 3 (456 +/- 162 ml) were significantly lower than in group 1 (1141 +/- 690 ml) (P < 0.05), although there was no significant difference between groups 2 and 3. The percentage of patients receiving transfusions during the operation in groups 1 and 2 were 57.1 and 5.6%, respectively.
CONCLUSIONS
The results show that a moderate reduction in SBP (80 - 100 mmHg) reduces blood loss by more than half in comparison to a mild reduction in SBP (100 - 120 mmHg). However, a severe reduction in SBP (60 - 80 mmHg) does not increase the reduction in blood loss in comparison to moderate hypotension.

Keyword

Anesthetic technique: induced hypotension; Hemorrhage: blood loss; Pharmacology: esmolol; hydralazine

MeSH Terms

Blood Pressure
Enflurane
Humans
Hydralazine
Hypotension*
Spinal Fusion
Enflurane
Hydralazine