Yeungnam Univ J Med.  1996 Dec;13(2):243-250. 10.12701/yujm.1996.13.2.243.

The Effects of Dimethly Sulfoxide and Sodium thiosulfate for the Prevention of Tissue Necrosis due to Extravasation of Mitomycin-C

• Woo SH
• Choi BC
• Kim KH
• Seul JH
• Jung TE

• KMID: 2154864
• DOI: http://doi.org/10.12701/yujm.1996.13.2.243

Abstract

Extravasation of toxic chemotherapeutic 'agents cause severe skin ulceration and necrosis which often need secondary surgical intervention. Still, there were not established antidote agent in case of extravasation with mitomycin-c. Dimethyl sulfoxide is known as an effective chemical scavenger of toxic hydroxyl free radical and sodium thiosulfate also was demonstrated significant protector from mitomycin-c induced ulceration by a few experimental studies. Author investigated necrotic area of mitomycin-c injected site and compare to the effectiveness of topical treatment with dimethyl sulfoxide and intradermal injection of sodium thiosulfate according to starting times, forty five mice were divided into 3 groups. Control group(n=5) had no treatment after subcutaneous injection of mitomycin-c. Experimental group I and 11 were 20 mice treated dimethyl sulfoxide and sodium.

Keyword

Extravasation injury; Mitomycn-C; DMSO; STS

MeSH Terms

Animals
Dimethyl Sulfoxide
Injections, Intradermal
Injections, Subcutaneous
Mice
Mitomycin*
Necrosis*
Skin Ulcer
Sodium*
Ulcer
Dimethyl Sulfoxide
Mitomycin
Sodium