Korean J Anesthesiol.  1997 Nov;33(5):918-922. 10.4097/kjae.1997.33.5.918.

Coagulation Status Changes during Progressive Hemodilution

• Choi YS
• Joun WJ
• Kim GS
• Hahm TS
• Kim CS
• Shin BH

• KMID: 2154488
• DOI: http://doi.org/10.4097/kjae.1997.33.5.918

Abstract

BACKGROUND: Hemodilution reduces the concentration of clotting factors in blood and this may induce some degree of impairment of coagulation. But there are some evidence that hemodilution may induce a hypercoagulable state. The goal of this study is to investigate the changes of coagulation status during progressive hemodilution.
METHODS
Whole Blood was diluted by 10% increment to 80% with 0.9% normal saline. At each 10% dilution blood coagulation status was analysed using thrombelastography (TEG) and was compared with that of an undiluted control specimen obtained concurrently from the same patients.
RESULTS
Hemodilutions up to 40% decrease r and K times and increase values of MA and angle. Hemodilutions more than 70% increase r and K times and decrease values of MA and angle.
CONCLUSIONS
Hemodilutions up to 40% increase coagulability and hemodilutions more than 70% decrease coagulability of whole blood in vitro.

Keyword

Blood, coagulation, hemodilution, thrombelastography

MeSH Terms

Blood Coagulation
Hemodilution*
Humans
Thrombelastography