Yeungnam Univ J Med.  1998 Jun;15(1):143-150. 10.12701/yujm.1998.15.1.143.

Comparison of Three Third-generation Anti-HCV Enzyme Immunoassay Tests

  • 1Department of Clinical Pathology College of Medicine, Yeungnam University Taegu, Korea.


The aim of this study was to evaluate domestic enzyme immunoassay(EIA) kit ?LG HCD 3.0?(LG) for the detection of antibody to hepatitis C virus(anti-HCV) in comparision with Axsym HCV version 3.0(Axsym), Cobas Core anti-HCV EIA(Cobas). Cobas kit shows better clear distinction between positive and negative by signal/cutoff ratio(S/C), but it also reveal relatively high false positive rate. The concordance rate of test results between LG and Axsym was 96.2%, between LG and Cobas was 95.5%, and total agreement between three EIA kit was 93.9%. LG were relative poor distinction between positive and negative results, but it could be applied clinically as a screening tool for hepatitis C in general population. The S/C of one false negative result by LG was 0.91, and false positive were less than 4.0, therefore we concluded it is necessary to confirm by immunoblotting assay when S/C were between 0.8 and 4.0.


Hepatitis C virus; Anti-HCV; Third-generation Enzyme Immunoassay

MeSH Terms

Hepatitis C
Immunoenzyme Techniques*
Mass Screening
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