Korean Circ J.  2014 May;44(3):156-161. 10.4070/kcj.2014.44.3.156.

A Pilot Study of Target Weight Guided Treatment in Acute Heart Failure Using Ultrafiltration or Usual Care: Effect on Sodium Removal

• Chung ES
• O'Brien TM
• Menon S
• Bartone C
• Mazur W
• Kereiakes

• KMID: 2145476
• DOI: http://doi.org/10.4070/kcj.2014.44.3.156

Abstract

BACKGROUND AND OBJECTIVES
In the Ultrafiltration versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure trial, ultrafiltration (UF) removed volume more effectively than usual care (UC). Hypothetically, UF may be superior to UC due to increased sodium (Na) removal and less neurohormonal activation. We compared UF and UC in a randomized pilot trial of target weight guided therapy for acute decompensated heart failure (ADHF).
SUBJECTS AND METHODS
Sixteen patients with ADHF were enrolled and target weights established prospectively, prior to randomization to UC or UF. UF patients did not receive diuretics and UC patients were all treated with a continuous furosemide drip. All urine and ultrafiltrate were collected and Na concentrations measured.
RESULTS
Similar volumes were removed in UC and UF groups (110105 mL and 107415 mL, respectively) and the UF group also produced 45325 mL of urine. Na concentration was 138+/-6 meq/L in the ultrafiltrate, 85+/-73 meq/L in the UC group's urine, and 26+/-23 meq/L in the UF group's urine. Given the relevant associated volumes, total meq of the Na removed was similar (1168 in UC vs. 1216 in UF). The UF group produced isotonic ultrafiltrate and a higher volume of dilute urine than anticipated.
CONCLUSION
In a randomized pilot study of target weight guided therapy with UC or UF for ADHF, there were no differences in total volumes or Na removed, and lengths of hospital stays were similar. Isotonic fluid loss by UF was accompanied by the production of very dilute urine.

Keyword

Ultrafiltration; Heart failure; Diuretics; Sodium

MeSH Terms

Diuretics
Furosemide
Heart Failure*
Humans
Length of Stay
Pilot Projects*
Prospective Studies
Random Allocation
Sodium*
Ultrafiltration*
Weights and Measures
Diuretics
Furosemide
Sodium

Figure

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  Fig. 1 A: assigning a patient to a three-component group based on degree of volume overload (mild: 0.1+ edema, moderate: 2.3+ edema, severe: 4+ edema), admission weight, and admission GFR. B: based on patient group, estimated target weight to be removed is obtained from the table. GFR: glomerular filtration rate.

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