Korean J Cytopathol.  2008 Sep;19(2):119-125. 10.3338/kjc.2008.19.2.119.

Comparison of Clinical Efficacy between an HPV DNA Chip and a Hybrid-Capture II Assay in a Patient with Abnormal Colposcopic Findings

• Kim TJ
• Jung CK
• Lee A
• Jung ES
• Choi YJ
• Lee KY
• Park JS

• KMID: 2144024
• DOI: http://doi.org/10.3338/kjc.2008.19.2.119

Abstract

This study was performed to compare the efficacy between a DNA chip method and a Hybrid-Capture II assay (HC-II) for detecting human papillomavirus in patients with intraepithelial lesions of the uterine cervix. From May, 2005, to June, 2006, 192 patients with abnormal colposcopic findings received cervical cytology, HC-II and HPV DNA chip tests, and colposcopic biopsy or conization. We compared the results of HC-II and HPV DNA chip in conjunction with liquid based cervical cytology (LBCC) and confirmed the results of biopsy or conization. The sensitivity of the HPV DNA chip test was higher than HC-II or LBCC. The HPV DNA chip in conjunction with LBCC showed higher sensitivity than any single method and higher sensitivity than HC-II with LBCC. We confirmed that the HPV DNA chip test was more sensitive for detecting HPV in cervical lesions than HC-II, and that it would provide more useful clinical information about HPV type and its multiple infections.

Keyword

HPV; HC-II; HPV DNA chip

MeSH Terms

Biopsy
Cervix Uteri
Conization
DNA
Female
Humans
Oligonucleotide Array Sequence Analysis
DNA